5-Aza-2/'-deoxycytidine

• CAT Number: I002785
• CAS Number: 2353-33-5
• Molecular Formula: C₈H₁₂N₄O₄
• Molecular Weight: 228.08
• Purity: ≥95%
• Target: DNA Methyltransferase
• Solubility: DMSO ≥43 mg/mL Water ≥9 mg/mL Ethanol ≥1.8 mg/mL
• Storage: -20°C
• IC50: 438 nM(HL-60); 4.38 nM(KG1a)
• IUPAC Name: 4-amino-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3,5-triazin-2-one
• InChI: InChI=1S/C8H12N4O4/c9-7-10-3-12(8(15)11-7)6-1-4(14)5(2-13)16-6/h3-6,13-14H,1-2H2,(H2,9,11,15)/t4-,5+,6+/m0/s1
• InChIKey: XAUDJQYHKZQPEU-KVQBGUIXSA-N
• SMILES: C1C(C(OC1N2C=NC(=NC2=O)N)CO)O

5-aza-2-deoxycytidine (Cat No.: I002785), also known as Deoxycytidine, is a DNA methyltransferase inhibitor, which integrates into DNA, causes DNA hypomethylation, and makes DNA replication stagnate in intra-S-phase. Decitabine is used to treat myelodysplastic syndrome (MDS). Decitabine induces cell cycle arrest and apoptosis in various cancer cell lines.

Reference

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