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5-Aminolevulinic acid HCl

5-Aminolevulinic acid HCl

  • CAT Number: A000919
  • CAS Number: 5451-09-2
  • Molecular Formula: C5H9NO3 • HCl
  • Molecular Weight: 167.6
  • Purity: ≥95%
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5-Aminolevulinic Acid HCl (CAS 5451-09-2)&nbsp;is an intermediate in the porphyrin synthesis pathway, used as a photosensitizing agent and a antineoplastic agent.<br />
5-aminolevulinic acid (5-ALA)-Photodynamic therapy (PDT) results in down regulation of nuclear factor kappa B (NFkappaB) and baculovirus inhibitor-of-apoptosis repeat containing-3 (BIRC-3) protein. 5-aminolevulinic acid (5-ALA)-Photodynamic therapy (PDT) causes increase in Bax:Bcl-2 ratio and mitochondrial release of cytochrome c and apoptosis-inducing factor (AIF).

Catalog Number A000919
CAS Number 5451-09-2
Molecular Formula

C5H9NO3 • HCl

Purity 95%
Storage 3 years -20C powder
IUPAC Name 5-amino-4-oxopentanoic acid;hydrochloride
InChI InChI=1S/C5H9NO3.ClH/c6-3-4(7)1-2-5(8)9;/h1-3,6H2,(H,8,9);1H
InChIKey ZLHFONARZHCSET-UHFFFAOYSA-N
SMILES C(CC(=O)O)C(=O)CN.Cl
Reference

<p>
<span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:12px;">1.<span style="font-variant-ligatures: normal; orphans: 2; widows: 2;">Malik, Z., et al. &quot;Topical application of 5-aminolevulinic acid, DMSO and EDTA: protoporphyrin IX accumulation in skin and tumours of mice.&quot;&nbsp;</span><i style="font-family: Arial, sans-serif; font-size: 13px; font-variant-ligatures: normal; orphans: 2; widows: 2;">Journal of Photochemistry and Photobiology B: Biology</i><span style="font-variant-ligatures: normal; orphans: 2; widows: 2;">&nbsp;28.3 (1995): 213-218.<br />
2.</span><span style="font-variant-ligatures: normal; orphans: 2; widows: 2;">Peng, Qian, et al. &quot;5‐Aminolevulinic acid‐based photodynamic therapy: clinical research and future challenges.&quot;&nbsp;</span><i style="font-family: Arial, sans-serif; font-size: 13px; font-variant-ligatures: normal; orphans: 2; widows: 2;">Cancer: Interdisciplinary International Journal of the American Cancer Society</i><span style="font-variant-ligatures: normal; orphans: 2; widows: 2;">&nbsp;79.12 (1997): 2282-2308.<br />
3.</span><span style="font-variant-ligatures: normal; orphans: 2; widows: 2;">Khaing Oo, Maung Kyaw, et al. &quot;5-aminolevulinic acid-conjugated gold nanoparticles for photodynamic therapy of cancer.&quot; (2008): 777-786.</span></span></span></p>

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