5β-Pregnan-3α-ol-20-one

• CAT Number: R001077
• CAS Number: 128-20-1
• Molecular Formula: C21H34O2
• Molecular Weight: 318.49
• Purity: ≥95%
• Target: GABA Receptor
• Solubility: Soluble in DMSO > 10 mM
• Storage: Store at RT

Pregnanolone, also known as Kabi-2213, SKF 6455, Eltanolone, is a cell membrane modulator potentially for the treatment of pain. Pregnanolone is an endogenous neurosteroid that is biosynthesized from progesterone. It is a positive allosteric modulator of the GABAA receptor, as well as a negative allosteric modulator of the glycine receptor, and is known to have sedative, anxiolytic, anesthetic, and anticonvulsant effects. It was investigated for clinical use as a general anesthetic, but produced unwanted side effects such as convulsions on occasion, and for that reason was never marketed.

Reference

1:The neurosteroid 5β-pregnan-3α-ol-20-one enhances actions of etomidate as a positive allosteric modulator of α1β2γ2L GABAA receptors. Li P, Bracamontes JR, Manion BD, Mennerick S, Steinbach JH, Evers AS, Akk G.Br J Pharmacol. 2014 Dec;171(23):5446-57. doi: 10.1111/bph.12861. PMID: 25117207 Free PMC Article2:5beta-Pregnan-3alpha-ol-20-one in urine. van der MOLEN H.Acta Endocrinol (Copenh). 1962 Oct;41:247-58. No abstract available. PMID: 13935824 3:Determination of micro-amounts of 5beta-pregnan-3alpha-ol-20-one in urine using infraredspectrometry. van der MOLEN H.Acta Endocrinol (Copenh). 1962 Oct;41:234-46. No abstract available. PMID: 13935823