CONTACT US
Home > Inhibitors/Agonists>Eukaryotic Initiation Factor (eIF)> > 4E1RCat
4E1RCat

4E1RCat

  • CAT Number: I003172
  • CAS Number: 328998-25-0
  • Molecular Formula: C28H18N2O6
  • Molecular Weight: 478.5
  • Purity: ≥95%
Inquiry Now

<p style=/line-height:25px/>4E1RCat is a dual inhibitor of eIF4E:eIF4G and eIF4E:4E-BP1 interaction, and inhibits the binding of eIF4G to eIF4E with IC50 of 3.2 μM.<br>IC50 value: 3.2 uM [1]<br>Target: eIF4E/eIF4G inhibitor<br>In in vitro translation experiments using MDA-MB-231 cells, 4E1RCat dose dependently inhibited cap-dependent translation, led to a decrease in polysome and 80S ribosomal subunits and reduced levels of the eIF4F-dependant proteins Mcl-1 and c-Myc.<br></p>

Catalog Number I003172
CAS Number 328998-25-0
Molecular Formula

C28H18N2O6

Purity 95%
Target eIF4E/eIF4G inhibitor
Solubility 10 mM in DMSO
Storage -20°C
IC50 3.2 uM [1]
InChI InChI=1S/C28H18N2O6/c31-27-21(16-24-14-15-26(36-24)19-6-12-23(13-7-19)30(34)35)17-25(18-4-2-1-3-5-18)29(27)22-10-8-20(9-11-22)28(32)33/h1-17H,(H,32,33)/b21-16-
InChIKey BBQRBOIMSKMFFO-PGMHBOJBSA-N
SMILES O=C1/C(C=C(C2=CC=CC=C2)N1C3=CC=C(C(O)=O)C=C3)=CC4=CC=C(C5=CC=C([N+]([O-])=O)C=C5)O4
Reference

<p style=/line-height:25px/>
<br>[1]. Liao G, et al. Immediate translation of Formin DIAPH1 mRNA after its exiting the nucleus is required for its perinuclear localization in fibroblasts. PLoS One. 2013 Jun 28;8(6):e68190.
</p>

Request a Quote

Contact Us at MuseChem

We are committed to providing you with reliable, cost-effective solutions for your chemical needs, while ensuring your safety and comfort. Our team of experts is always available to answer your questions and help you navigate the complexities of the chemical industry.

Whether you're looking for a specific product or need help with a custom synthesis project, we're here to help you discover a new world of chemical possibilities. Contact us today to learn more about how we can assist you with all of your chemical needs.

Our goal is to make the process of ordering chemicals as seamless and hassle-free as possible. Let us know how we can assist you, and we'll get back to you as soon as possible. We look forward to hearing from you!