4-Hydroxyatomoxetine

• CAT Number: R006026
• CAS Number: 435293-66-6
• Molecular Formula: C17H21NO2
• Molecular Weight: 271.35
• Purity: ≥95%
• Synonyms: 3-methyl-4-[(1R)-3-(methylamino)-1-phenylpropoxy]phenol
• InChI: InChI=1S/C17H21NO2/c1-13-12-15(19)8-9-16(13)20-17(10-11-18-2)14-6-4-3-5-7-14/h3-9,12,17-19H,10-11H2,1-2H3/t17-/m1/s1
• InChIKey: PPXQPRLGNSJNJM-QGZVFWFLSA-N
• SMILES: CC1=C(C=CC(=C1)O)OC(CCNC)C2=CC=CC=C2

4-Hydroxyatomoxetine(CAT: R006026) is the primary active metabolite of Atomoxetine, a selective norepinephrine reuptake inhibitor (NRI) widely used for the treatment of attention-deficit hyperactivity disorder (ADHD). Formed via CYP2D6-mediated hydroxylation, 4-Hydroxyatomoxetine retains strong activity at the norepinephrine transporter, contributing substantially to the clinical efficacy of Atomoxetine. This metabolite is commonly used as a reference standard in pharmacokinetic, metabolic stability, and drug–drug interaction studies. It also plays a crucial role in understanding CYP2D6 genetic polymorphisms, which influence Atomoxetine’s metabolism and therapeutic outcomes. 4-Hydroxyatomoxetine is therefore valuable for neurological disease research, pharmacogenomics, and CNS drug metabolism investigations.