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Home > Reference Standards> > 4-(1H-Pyrazol-4-yl)-7-[[2-(trimethylsilyl)ethoxy]methyl]-7H-pyrrolo[2,3-d]pyrimidine
4-(1H-Pyrazol-4-yl)-7-[[2-(trimethylsilyl)ethoxy]methyl]-7H-pyrrolo[2,3-d]pyrimidine

4-(1H-Pyrazol-4-yl)-7-[[2-(trimethylsilyl)ethoxy]methyl]-7H-pyrrolo[2,3-d]pyrimidine

  • CAT Number: R057404
  • CAS Number: 941685-27-4
  • Molecular Formula: C15H21N5OSi
  • Molecular Weight: 315.452
  • Purity: ≥95%
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4-(1H-Pyrazol-4-yl)-7-[[2-(trimethylsilyl)ethoxy]methyl]-7H-pyrrolo[2,3-d]pyrimidine is an important intermediate in the preparation of the janus kinase inhibitor <a href=/http://www.musechem.com/product/I008849.html/ target=/_blank/>Ruxolitinib phosphate(<span style=/color:#333333;font-family:Arial;font-size:14px;/>I008849</span>)</a>.

Catalog Number R057404
CAS Number 941685-27-4
Molecular Formula

C15H21N5OSi

Purity 95%
Storage Store at +4C
IUPAC Name trimethyl-[2-[[4-(1H-pyrazol-4-yl)pyrrolo[2,3-d]pyrimidin-7-yl]methoxy]ethyl]silane
InChI InChI=1S/C15H21N5OSi/c1-22(2,3)7-6-21-11-20-5-4-13-14(12-8-18-19-9-12)16-10-17-15(13)20/h4-5,8-10H,6-7,11H2,1-3H3,(H,18,19)
InChIKey AVMLPTWVYQXRSV-UHFFFAOYSA-N
SMILES C[Si](C)(C)CCOCN1C=CC2=C(N=CN=C21)C3=CNN=C3
Reference

1. Enantioselective Synthesis of Janus Kinase Inhibitor INCB018424 via an Organocatalytic Aza-Michael Reaction <br />
<br />
Qiyan Lin*, David Meloni, Yongchun Pan, Michael Xia, James Rodgers, Stacey Shepard, Mei Li, Laurine Galya, Brian Metcalf, Tai-Yuen Yue, Pingli Liu and Jiacheng Zhou
Incyte Corporation, Experimental Station, Route 141 and Henry Clay Road, Wilmington, Delaware 19880
Org. Lett., 2009, 11 (9), pp 1999–2002
DOI: 10.1021/ol900350k

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