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Home > Reference Standards>Cannabinoid Receptor> > (3S,8S,9R,10S,13S,14R,17R)-17-acetyl-10,13-dimethyl-3-sulfooxy-2,3,4,7,8,9,11,12,14,15,16,17-dodecah
(3S,8S,9R,10S,13S,14R,17R)-17-acetyl-10,13-dimethyl-3-sulfooxy-2,3,4,7,8,9,11,12,14,15,16,17-dodecah

(3S,8S,9R,10S,13S,14R,17R)-17-acetyl-10,13-dimethyl-3-sulfooxy-2,3,4,7,8,9,11,12,14,15,16,17-dodecah

  • CAT Number: M049920
  • CAS Number: 1247-64-9
  • Molecular Formula: C21H32O5S
  • Molecular Weight: 396.542
  • Purity: ≥95%
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<span style="color:#000000;"><span style="font-size:12px;"><span style="font-family:arial,helvetica,sans-serif;">(3S,8S,9R,10S,13S,14R,17R)-17-acetyl-10,13-dimethyl-3-sulfooxy-2,3,4,7,8,9,11,12,14,15,16,17-dodecah (CAS&nbsp;1247-64-9), also known as pregnenolone monosulfate,&nbsp;<span style="text-align: justify;">&nbsp;is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone monosulfate acts as a signaling-specific inhibitor of cannabinoid CB1 receptor</span><span style="text-align: justify;">, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors</span><span style="text-align: justify;">. Pregnenolone monosulfate can protect the brain from cannabis intoxication.</span></span></span></span>

Catalog Number M049920
CAS Number 1247-64-9
Molecular Formula

C21H32O5S

Purity 95%
Storage -20°C
IUPAC Name [(3S,8S,9S,10R,13S,14S,17S)-17-acetyl-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] hydrogen sulfate
InChI InChI=1S/C21H32O5S/c1-13(22)17-6-7-18-16-5-4-14-12-15(26-27(23,24)25)8-10-20(14,2)19(16)9-11-21(17,18)3/h4,15-19H,5-12H2,1-3H3,(H,23,24,25)/t15-,16-,17+,18-,19-,20-,21+/m0/s1
InChIKey DIJBBUIOWGGQOP-QGVNFLHTSA-N
SMILES CC(=O)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)OS(=O)(=O)O)C)C
Reference

<span style="color:#000000;"><span style="font-size:12px;"><span style="font-family:arial,helvetica,sans-serif;">1.Vall&eacute;e, Monique, et al. &quot;Pregnenolone can protect the brain from cannabis intoxication.&quot;&nbsp;<i style="font-family: Arial, sans-serif; font-size: 13px;">Science</i>&nbsp;343.6166 (2014): 94-98.<br />
2.Ducharme, Nicole, et al. &quot;Brain distribution and behavioral effects of progesterone and pregnenolone after intranasal or intravenous administration.&quot;&nbsp;<i style="font-family: Arial, sans-serif; font-size: 13px;">European journal of pharmacology</i>&nbsp;641.2-3 (2010): 128-134.</span></span></span>

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