3BrB-PP1

• CAT Number: R058248
• CAS Number: 956025-99-3
• Molecular Formula: C16H18BrN5
• Molecular Weight: 360.25
• Purity: ≥95%
• Synonyms: 3-[(3-bromophenyl)methyl]-1-tert-butylpyrazolo[3,4-d]pyrimidin-4-amine
• InChI: InChI=1S/C16H18BrN5/c1-16(2,3)22-15-13(14(18)19-9-20-15)12(21-22)8-10-5-4-6-11(17)7-10/h4-7,9H,8H2,1-3H3,(H2,18,19,20)
• InChIKey: FTICVONBLRGQJW-UHFFFAOYSA-N
• SMILES: CC(C)(C)N1C2=NC=NC(=C2C(=N1)CC3=CC(=CC=C3)Br)N

3BrB-PP1 (Cat No.: R058248) is a synthetic small-molecule ATP-competitive kinase inhibitor designed as a chemical probe for studying engineered “analog-sensitive” kinases. By incorporating a bulky bromobenzyl substituent, 3BrB-PP1 selectively inhibits kinases mutated to accommodate this analog while sparing most wild-type kinases. This high degree of specificity enables researchers to dissect kinase signaling pathways, substrate identification, and functional roles in cellular processes. 3BrB-PP1 is widely applied in chemical genetics, signal transduction research, and drug discovery as a precise tool for kinase biology.

Reference

[1]. Tay YD, et, al. Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex. Cell Rep. 2019 Feb 5;26(6):1654-1667.e7.
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[2]. Mutavchiev DR, et, al. Remodeling of the Fission Yeast Cdc42 Cell-Polarity Module via the Sty1 p38 Stress-Activated Protein Kinase Pathway. Curr Biol. 2016 Nov 7;26(21):2921-2928.
[Content Brief]