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3-BETA-CHLORO-IMPERIALINE

3-BETA-CHLORO-IMPERIALINE

  • CAT Number: M092233
  • CAS Number: 153720-49-1
  • Molecular Formula: C27H42ClNO2
  • Molecular Weight: 448.088
  • Purity: ≥95%
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<p>It is a potent medium-lasting selective M<sub>2</sub> muscarinic receptor antagonist.</p><br />Cervane alkaloid<!–C<SUB>27</SUB>H<SUB>42</SUB>CINO<SUB>2</SUB>–>, derivative of Imperialine from the plant <I>Petilium eduardi</I>.</br><p><strong>3-beta-Chloro-Imperialine</strong>, a medium-lasting cholinoblocker of M<sub>2</sub> receptors, blocks M<sub>2</sub> receptors in the heart at 10 &mu;g/kg (i.v.). <strong>3-beta-Chloro-Imperialine</strong>/’s activity is 10 times higher than that of Imperialine.</p></br>

Catalog Number M092233
CAS Number 153720-49-1
Molecular Formula

C27H42ClNO2

Purity 95%
Storage Store at -20°C
InChI InChI=1S/C27H42ClNO2/c1-15-4-7-25-27(3,31)21-6-5-17-18(20(21)14-29(25)13-15)11-22-19(17)12-24(30)23-10-16(28)8-9-26(22,23)2/h15-23,25,31H,4-14H2,1-3H3/t15-,16-,17+,18+,19-,20-,21+,22-,23+,25-,26+,27-/m0/s1
InChIKey VXTAIQOZSINDOZ-LRCDAWNTSA-N
SMILES CC1CCC2C(C3CCC4C(C3CN2C1)CC5C4CC(=O)C6C5(CCC(C6)Cl)C)(C)O
Reference

– Eglen et al., /Characterisation of the interaction of the cervane alkaloid, imperialine, at Muscarinic receptors in vitro./ <I>Naunyn-Schmiedeberg�s Arch. Pharmacol</I>. (1992) 346:144-151<br /><br />- Mirzaev, unbublished results on 3-beta-Bromo-Imperialine<br /><br /><br /><br />

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