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3β,12β,14-Trihydroxy-11-oxo-5β-bufa-20,22-dienolide

3β,12β,14-Trihydroxy-11-oxo-5β-bufa-20,22-dienolide

  • CAT Number: M086245
  • CAS Number: 17008-65-0
  • Molecular Formula: C24H32O6
  • Molecular Weight: 416.514
  • Purity: 98%
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3,12,14-Trihydroxy-11-oxo-5-bufa-20,22-dienolide (CAS17008-65-0)has inhibitory activity on human kidney Na(+)/K(+)-ATPase, it has cytotoxicity against HepG2 and MCF-7 human cancer cells.

Catalog Number M086245
CAS Number 17008-65-0
Molecular Formula

C24H32O6

Purity 98
Storage Store at -20°C
IUPAC Name 5-[(3S,5R,8R,9S,10S,12S,13S,14S,17R)-3,12,14-trihydroxy-10,13-dimethyl-11-oxo-2,3,4,5,6,7,8,9,12,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]pyran-2-one
InChI InChI=1S/C24H32O6/c1-22-9-7-15(25)11-14(22)4-5-17-19(22)20(27)21(28)23(2)16(8-10-24(17,23)29)13-3-6-18(26)30-12-13/h3,6,12,14-17,19,21,25,28-29H,4-5,7-11H2,1-2H3/t14-,15+,16-,17-,19-,21-,22+,23+,24+/m1/s1
InChIKey SOGONHOGEFLVPE-PUVOGLICSA-N
SMILES CC12CCC(CC1CCC3C2C(=O)C(C4(C3(CCC4C5=COC(=O)C=C5)O)C)O)O
Reference

<p>
<span style=”color:#000000;”><span style=”font-size:12px;”><span style=”font-family:arial,helvetica,sans-serif;”>1.C&oacute;rdova, Wilmer H. Perera, et al. &quot;Bufadienolides from parotoid gland secretions of Cuban toad Peltophryne fustiger (Bufonidae): Inhibition of human kidney Na+/K+-ATPase activity.&quot;&nbsp;<i style=”font-family: Arial, sans-serif; font-size: 13px;”>Toxicon</i>&nbsp;110 (2016): 27-34.<br />
2.C&oacute;rdova, Wilmer H. Perera, et al. &quot;Bufadienolides from parotoid gland secretions of Cuban toad Peltophryne fustiger (Bufonidae): Inhibition of human kidney Na+/K+-ATPase activity.&quot;&nbsp;<i style=”font-family: Arial, sans-serif; font-size: 13px;”>Toxicon</i>&nbsp;110 (2016): 27-34.<br />
3.Zhang, Xing, et al. &quot;Biotransformation of arenobufagin and cinobufotalin by Alternaria alternata.&quot;&nbsp;<i style=”font-family: Arial, sans-serif; font-size: 13px;”>Biocatalysis and Biotransformation</i>&nbsp;29.2-3 (2011): 96-101.</span></span></span></p>

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