2-Thiohydantoin

• CAT Number: R044996
• CAS Number: 503-87-7
• Molecular Formula: C3H4N2OS
• Molecular Weight: 116.138
• Purity: ≥95%
• Storage: Desiccate at RT
• IUPAC Name: 2-sulfanylideneimidazolidin-4-one
• InChI: InChI=1S/C3H4N2OS/c6-2-1-4-3(7)5-2/h1H2,(H2,4,5,6,7)
• InChIKey: UGWULZWUXSCWPX-UHFFFAOYSA-N
• SMILES: C1C(=O)NC(=S)N1

Thiohydantoin, also known as 2-Thiohydantoin and NSC 11772, is a potent inhibitors of mutant IDH1. Thiohydantoin can decrease the cellular concentration of D2HG, reduce the levels of histone methylation, and suppress the proliferation of stem-like cancer cells in BT142 glioma with IDH1 R132H mutation. Somatic mutations of isocitrate dehydrogenase 1 (IDH1) at R132 are frequently found in certain cancers such as glioma. With losing the activity of wild-type IDH1, the R132H and R132C mutant proteins can reduce α-ketoglutaric acid (α-KG) to d-2-hydroxyglutaric acid (D2HG).

Reference

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