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Home > Reference Standards>NF-κB> > 2-Propen-1-one, 3-(3,4-dihydroxy-2-Methoxyphenyl)-1-[4-hydroxy-3-(3-Methyl-2-butenyl)p henyl]-, (E)-
2-Propen-1-one, 3-(3,4-dihydroxy-2-Methoxyphenyl)-1-[4-hydroxy-3-(3-Methyl-2-butenyl)p henyl]-, (E)-

2-Propen-1-one, 3-(3,4-dihydroxy-2-Methoxyphenyl)-1-[4-hydroxy-3-(3-Methyl-2-butenyl)p henyl]-, (E)-

  • CAT Number: M133565
  • CAS Number: 144506-15-0
  • Molecular Formula: C21H22O5
  • Molecular Weight: 354.402
  • Purity: ≥95%
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2-Propen-1-one, 3-(3,4-dihydroxy-2-Methoxyphenyl)-1-[4-hydroxy-3-(3-Methyl-2-butenyl)p henyl]-, (E)- (CAS144506-15-0), also known asLicochalcone D,a flavonoid compound mainly existing in the root of Glycyrrhiza inflate, is a potent inhibitor of NF-kappaB p65. Itis a chalcone with antioxidant, anti-inflammatory and anti-cancer properties.

Catalog Number M133565
CAS Number 144506-15-0
Molecular Formula

C21H22O5

Purity 95%
Storage -20°C
IUPAC Name (E)-3-(3,4-dihydroxy-2-methoxyphenyl)-1-[4-hydroxy-3-(3-methylbut-2-enyl)phenyl]prop-2-en-1-one
InChI InChI=1S/C21H22O5/c1-13(2)4-5-15-12-16(8-10-18(15)23)17(22)9-6-14-7-11-19(24)20(25)21(14)26-3/h4,6-12,23-25H,5H2,1-3H3/b9-6+
InChIKey RETRVWFVEFCGOK-RMKNXTFCSA-N
SMILES CC(=CCC1=C(C=CC(=C1)C(=O)C=CC2=C(C(=C(C=C2)O)O)OC)O)C
Reference

<span style=”color:#000000;”><span style=”font-size:12px;”><span style=”font-family:arial,helvetica,sans-serif;”>1.Furusawa, Jun-ichi, et al. &quot;Glycyrrhiza inflata-derived chalcones, Licochalcone A, Licochalcone B and Licochalcone D, inhibit phosphorylation of NF-&kappa;B p65 in LPS signaling pathway.&quot;&nbsp;<i style=”font-family: Arial, sans-serif; font-size: 13px;”>International immunopharmacology</i>&nbsp;9.4 (2009): 499-507.<br />
2.Oh, Ha-Na, et al. &quot;Licochalcone D induces ROS-dependent apoptosis in gefitinib-sensitive or resistant lung cancer cells by targeting EGFR and MET.&quot;&nbsp;<i style=”font-family: Arial, sans-serif; font-size: 13px;”>Biomolecules</i>&nbsp;10.2 (2020): 297.</span></span></span>

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