2'-DEOXY-N6-METHYLADENOSINE 3',5'-BISPHOSPHATE TETRAAMMONIUM SALT

• CAT Number: M012067
• CAS Number: 101204-49-3
• Molecular Formula: C11H17N5O9P2
• Molecular Weight: 425.2
• Purity: ≥95%
• Storage: -20°C
• InChI: InChI=1S/C11H17N5O9P2/c1-12-10-9-11(14-4-13-10)16(5-15-9)8-2-6(25-27(20,21)22)7(24-8)3-23-26(17,18)19/h4-8H,2-3H2,1H3,(H,12,13,14)(H2,17,18,19)(H2,20,21,22)/p-2
• InChIKey: CCPLITQNIFLYQB-XLPZGREQSA-N
• SMILES: CNC1=NC=NC2=C1N=CN2[C@H]3C[C@H](OP(O)(O)=O)[C@@H](COP(O)(O)=O)O3

MRS2179 is a competitive P2Y1 receptor antagonist (Kb = 100 nM) with no appreciable activity at P2Y2, P2Y4, or P2Y6 at concentrations up to 30 µM, or at P2Y12 and P2Y13. It inhibits ADP-induced platelet shape change and aggregation (pA2 = 6.55) in vitro and prolongs bleeding time in rats and mice compared to controls.

Reference

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