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2’-Deoxy-3’,5’-di-O-benzoyl-2’,2’-difluorocytidine

2’-Deoxy-3’,5’-di-O-benzoyl-2’,2’-difluorocytidine

  • CAT Number: R008574
  • CAS Number: 134790-39-9
  • Molecular Formula: C₂₃H₁₉F₂N₃O₆
  • Molecular Weight: 471.41
  • Purity: ≥95%
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<span style="color:#000000;"><span style="font-size:12px;"><span style="font-family:arial,helvetica,sans-serif;">2&rsquo;-Deoxy-3&rsquo;,5&rsquo;-di-O-benzoyl-2&rsquo;,2&rsquo;-difluorocytidine (CAS&nbsp;134790-39-9)&nbsp;is an intermediate of gemcitabine with antitumor properties.</span></span></span>

Catalog Number R008574
CAS Number 134790-39-9
Molecular Formula

C₂₃H₁₉F₂N₃O₆

Purity 95%
Storage Store at -20°C
IUPAC Name [(2R,3R,5R)-5-(4-amino-2-oxopyrimidin-1-yl)-3-benzoyloxy-4,4-difluorooxolan-2-yl]methyl benzoate
InChI InChI=1S/C23H19F2N3O6/c24-23(25)18(34-20(30)15-9-5-2-6-10-15)16(13-32-19(29)14-7-3-1-4-8-14)33-21(23)28-12-11-17(26)27-22(28)31/h1-12,16,18,21H,13H2,(H2,26,27,31)/t16-,18-,21-/m1/s1
InChIKey ZPUUYUUQQGBHBU-HGHGUNKESA-N
SMILES C1=CC=C(C=C1)C(=O)OCC2C(C(C(O2)N3C=CC(=NC3=O)N)(F)F)OC(=O)C4=CC=CC=C4
Reference

<span style="color:#000000;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:12px;">1.Abbruzzese, James L., et al. &quot;A phase I clinical, plasma, and cellular pharmacology study of gemcitabine.&quot;&nbsp;<i style="font-family: Arial, sans-serif; font-size: 13px;">Journal of Clinical Oncology</i>&nbsp;9.3 (1991): 491-498.<br />
2.Hertel, Larry W., et al. &quot;Evaluation of the antitumor activity of gemcitabine (2&prime;, 2&prime;-difluoro-2&prime;-deoxycytidine).&quot;&nbsp;<i style="font-family: Arial, sans-serif; font-size: 13px;">Cancer research</i>&nbsp;50.14 (1990): 4417-4422.<br />
3.van Haperen, Veronique WT Ruiz, et al. &quot;2&prime;, 2&prime;-Difluoro-deoxycytidine (gemcitabine) incorporation into RNA and DNA of tumour cell lines.&quot;&nbsp;<i style="font-family: Arial, sans-serif; font-size: 13px;">Biochemical pharmacology</i>&nbsp;46.4 (1993): 762-766.</span></span></span>

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