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2-amino-1-(4-chlorobenzyl)-5-trifluoromethylbenzimidazole

2-amino-1-(4-chlorobenzyl)-5-trifluoromethylbenzimidazole

  • CAT Number: M103997
  • CAS Number: 150493-34-8
  • Molecular Formula: C10H16N2O3S
  • Purity: ≥95%
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NS-638 is a Ca(2+)-channel blocker. NS-638 dose dependently inhibited K(+)-stimulated [45Ca2+]-uptake in chick cortical synaptosomes and 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid (AMPA)-stimulated [3H]GABA-release from cultured cortical neurons with IC50 values of 2.3 and 4.3 microM, respectively. K(+)-stimulated intracellular Ca(2+)-elevation in cultured cerebellar granule cells was equipotently blocked with an IC50 value of 3.4 microM.

Catalog Number M103997
CAS Number 150493-34-8
Molecular Formula

C10H16N2O3S

Purity 95%
Storage Desiccate at +4C
InChI InChI=1S/C15H11ClF3N3/c16-11-4-1-9(2-5-11)8-22-13-6-3-10(15(17,18)19)7-12(13)21-14(22)20/h1-7H,8H2,(H2,20,21)
InChIKey GXQCVUZORDAARJ-UHFFFAOYSA-N
SMILES FC(C1=CC=C2C(N=C(N)N2CC3=CC=C(Cl)C=C3)=C1)(F)F
Reference

</br>1: Møller A, Christophersen P, Drejer J, Axelsson O, Peters D, Jensen LH, Nielsen</br> EO. Pharmacological profile and anti-ischemic properties of the Ca(2+)-channel</br> blocker NS-638. Neurol Res. 1995 Oct;17(5):353-60. PubMed PMID: 8584126.</br>2: Olesen SP, Møller A, Mordvintcev PI, Busse R, Mülsch A. Regional measurements </br> of NO formed in vivo during brain ischemia. Acta Neurol Scand. 1997</br> Apr;95(4):219-24. PubMed PMID: 9150812.</br></br>

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