2-[[2-(4-Bromophenyl)-6-methyl-4-pyrinidinyl]amino]ethanol

• CAT Number: R041585
• CAS Number: 330981-72-1
• Molecular Formula: C13H14BrN3O
• Molecular Weight: 308.179
• Purity: ≥95%
• Target: GPR119
• Solubility: Soluble in DMSO > 10 mM
• Storage: Store at -20C
• IUPAC Name: 2-[[2-(4-bromophenyl)-6-methylpyrimidin-4-yl]amino]ethanol
• InChI: InChI=1S/C13H14BrN3O/c1-9-8-12(15-6-7-18)17-13(16-9)10-2-4-11(14)5-3-10/h2-5,8,18H,6-7H2,1H3,(H,15,16,17)
• InChIKey: DUKPGOOUJNUIOI-UHFFFAOYSA-N
• SMILES: CC1=CC(=NC(=N1)C2=CC=C(C=C2)Br)NCCO

AS1269574 is a GPR119 agonist.

Reference

1: Chepurny OG, Holz GG, Roe MW, Leech CA. GPR119 Agonist AS1269574 Activates TRPA1 Cation Channels to Stimulate GLP-1 Secretion. Mol Endocrinol. 2016 Jun;30(6):614-29. doi: 10.1210/me.2015-1306. PubMed PMID: 27082897; PubMed Central PMCID: PMC4884340.2: Moran BM, Abdel-Wahab YH, Flatt PR, McKillop AM. Activation of GPR119 by fatty acid agonists augments insulin release from clonal β-cells and isolated pancreatic islets and improves glucose tolerance in mice. Biol Chem. 2014 Apr;395(4):453-64. doi: 10.1515/hsz-2013-0255. PubMed PMID: 24323890.3: Chepurny OG, Bertinetti D, Diskar M, Leech CA, Afshari P, Tsalkova T, Cheng X, Schwede F, Genieser HG, Herberg FW, Holz GG. Stimulation of proglucagon gene expression by human GPR119 in enteroendocrine L-cell line GLUTag. Mol Endocrinol. 2013 Aug;27(8):1267-82. doi: 10.1210/me.2013-1029. PubMed PMID: 23798572; PubMed Central PMCID: PMC3725342.4: Yoshida S, Ohishi T, Matsui T, Tanaka H, Oshima H, Yonetoku Y, Shibasaki M. Novel GPR119 agonist AS1535907 contributes to first-phase insulin secretion in rat perfused pancreas and diabetic db/db mice. Biochem Biophys Res Commun. 2010 Nov 12;402(2):280-5. doi: 10.1016/j.bbrc.2010.10.015. PubMed PMID: 20937249.5: Yoshida S, Tanaka H, Oshima H, Yamazaki T, Yonetoku Y, Ohishi T, Matsui T, Shibasaki M. AS1907417, a novel GPR119 agonist, as an insulinotropic and β-cell preservative agent for the treatment of type 2 diabetes. Biochem Biophys Res Commun. 2010 Oct 1;400(4):745-51. doi: 10.1016/j.bbrc.2010.08.141. PubMed PMID: 20816753.6: Yoshida S, Ohishi T, Matsui T, Shibasaki M. Identification of a novel GPR119 agonist, AS1269574, with in vitro and in vivo glucose-stimulated insulin secretion. Biochem Biophys Res Commun. 2010 Sep 24;400(3):437-41. doi: 10.1016/j.bbrc.2010.08.097. PubMed PMID: 20804735.