1A-116

• CAT Number: I020467
• CAS Number: 1430208-73-3
• Molecular Formula: C₁₆H₁₆F₃N₃
• Molecular Weight: 307.31
• Purity: ≥95%
• Storage: Store at -20°C
• IUPAC Name: 1-(3,5-dimethylphenyl)-2-[2-(trifluoromethyl)phenyl]guanidine
• InChI: InChI=1S/C16H16F3N3/c1-10-7-11(2)9-12(8-10)21-15(20)22-14-6-4-3-5-13(14)16(17,18)19/h3-9H,1-2H3,(H3,20,21,22)
• InChIKey: DVIJFJSZZNOTLP-UHFFFAOYSA-N
• SMILES: CC1=CC(=CC(=C1)NC(=NC2=CC=CC=C2C(F)(F)F)N)C

1A-116（Cat No.:I020467） is a specific inhibitor of Rac1, a protein involved in cellular processes related to tumor growth and metastasis. It exhibits potent antitumoral and antimetastatic effects in various cancer types, including breast cancer. By inhibiting Rac1, 1A-116 disrupts Rac1-regulated processes crucial for primary tumor development and metastasis. This compound shows promise as a therapeutic agent in targeting key signaling pathways associated with cancer progression, offering potential benefits in suppressing tumor growth and inhibiting metastatic spread in breast cancer and other malignancies.

Reference

[1]. Cardama GA, et al. Preclinical development of novel Rac1-GEF signaling inhibitors using a rational design approach in highly aggressive breast cancer cell lines. Anticancer Agents Med Chem. 2014;14(6):840-51.[2]. Nazareno González, et al. Computational and in vitro Pharmacodynamics Characterization of 1A-116 Rac1 Inhibitor: Relevance of Trp56 in Its Biological Activity. Front Cell Dev Biol. 2020 Apr 15;8:240.