18-Hydroxyprogesterone

• CAT Number: C001115
• CAS Number: 596-69-0
• Molecular Formula: C₂₁H₃₀O₃
• Molecular Weight: 330.46
• Purity: ≥95%
• Synonyms: 18-Hydroxypregn-4-ene-3,20-dione
• Solubility: Chlorofrom (Slightly), Methanol (Sligthly)
• Storage: -20°C, Inert atmosphere
• IUPAC Name: (8R,9S,10R,13R,14S,17S)-17-acetyl-13-(hydroxymethyl)-10-methyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
• InChI: InChI=1S/C21H30O3/c1-13(23)17-5-6-19-16-4-3-14-11-15(24)7-9-20(14,2)18(16)8-10-21(17,19)12-22/h11,16-19,22H,3-10,12H2,1-2H3/t16-,17-,18+,19+,20+,21+/m1/s1
• InChIKey: QFNCSEWPJSDMED-OFELHODLSA-N
• SMILES: CC(=O)C1CCC2C1(CCC3C2CCC4=CC(=O)CCC34C)CO

18-Hydroxyprogesterone (Cat No.:C001115) is a natural steroid hormone and an intermediate in the biosynthesis of other steroid hormones, including cortisol and aldosterone. It is produced in the adrenal glands and plays a role in various physiological processes, such as regulating the menstrual cycle and supporting pregnancy. Additionally, 18-Hydroxyprogesterone is used in medicine as a precursor for the synthesis of synthetic corticosteroids. It is also measured in diagnostic tests to assess adrenal function and screen for congenital adrenal hyperplasia.

Reference

Anderson, E., et al.: Breast Cancer Res., 4, 197 (2002), Lanari, C., et al.: Breast Cancer Res., 4, 240 (2002), Albrecht, E.D., et al.: Front. Biosci., 8, 416 (2003), Qiu, M., et al.: J. Steroid Biochem. Mol. Biol., 85, 147 (2003),