17β-Estradiol-d2

• CAT Number: R067693
• CAS Number: 53866-33-4
• Molecular Formula: C18H24O2
• Molecular Weight: 274.4
• Purity: ≥95%
• Synonyms: 2,4-Dideuteriostradiol;E2-d2;Estradiol-d2;β-Estradiol-d2;17β-Oestradiol-d2
• Storage: -20°C
• IUPAC Name: (8R,9S,13S,14S,17S)-2,4-dideuterio-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol
• InChI: InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1/i3D,10D
• InChIKey: VOXZDWNPVJITMN-JXCLBMSPSA-N
• SMILES: CC12CCC3C(C1CCC2O)CCC4=C3C=CC(=C4)O

17β-Estradiol-d2 is intended for use as an internal standard for the quantification of 17β-estradiol (Item Nos. ISO60155 | 10006315) by GC- or LC-MS. 17β-Estradiol is the major estrogen secreted by the premenopausal ovary. It is synthesized from testosterone primarily in the ovarian granulosa cells and placenta, but small amounts can be produced in the adrenal gland. Plasma 17β-estradiol levels increase gradually between days 1-7 of the menstrual cycle followed by a sharp increase to a peak value of about 300 pg/ml on day 12, just prior to ovulation.

Reference

1.Vance, D.E. Cholesterol and related derivatives. Biochemistry 2nd ed., 725-748 (1988).