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15-Lipoxygenase Inhibitor 1

15-Lipoxygenase Inhibitor 1

  • CAT Number: R039495
  • CAS Number: 928853-86-5
  • Molecular Formula: C16H19N5S
  • Molecular Weight: 313.423
  • Purity: ≥95%
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Lipoxygenases (LOs) are non-<wbr></wbr>heme iron-<wbr></wbr>containing dioxygenases that catalyze the oxidation of polyunsaturated fatty acids to generate unsaturated fatty acid hydroperoxides. The immediate products of 15-<wbr></wbr>LO fatty acid oxidation act as mediators in inflammation, thrombosis, and cancer. 15-<wbr></wbr>Lipoxygenases (15-<wbr></wbr>LO) inhibitor 1 is a heterocyclic pyrimidobenzothiazine compound that inhibits 15-<wbr></wbr>LO with an IC<sub>50</sub> value of 18 µM. The inhibitor appears to act as an antioxidant, interfering with the redox cycle of 15-<wbr></wbr>LO.

Catalog Number R039495
CAS Number 928853-86-5
Molecular Formula

C16H19N5S

Purity 95%
Storage -20°C
IUPAC Name 4-methyl-2-(4-methylpiperazin-1-yl)-5H-pyrimido[4,5-b][1,4]benzothiazine
InChI InChI=1S/C16H19N5S/c1-11-14-15(22-13-6-4-3-5-12(13)18-14)19-16(17-11)21-9-7-20(2)8-10-21/h3-6,18H,7-10H2,1-2H3
InChIKey HYPHGMNLWIKEMB-UHFFFAOYSA-N
SMILES CC1=C2C(=NC(=N1)N3CCN(CC3)C)SC4=CC=CC=C4N2
Reference

1.Gaffney, B.J. Lipoxygenases: Structural principles and spectroscopy. Annual Reviews of Biophysical and Biomolecular Structure 25, 431-459 (1996).

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