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1,2-Dioleoyl-rac-glycerol

1,2-Dioleoyl-rac-glycerol

  • CAT Number: R027359
  • CAS Number: 2442-61-7
  • Molecular Formula: C39H72O5
  • Molecular Weight: 621
  • Purity: ≥95%
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1,2-<wbr />Dioleoyl-<wbr /><em>rac</em>-<wbr />glycerol (CAS 2442-61-7) is a form of diacylglycerol (DAG) where both acyl groups consist of the 18:1 oleoyl chain. It effectively binds the C1 domain to activate conventional protein kinase C forms and serves as a substrate for DAG kinases and multisubstrate lipid kinase.

Catalog Number R027359
CAS Number 2442-61-7
Molecular Formula

C39H72O5

Purity 95%
Storage -80°C
IUPAC Name [3-hydroxy-2-[(Z)-octadec-9-enoyl]oxypropyl] (Z)-octadec-9-enoate
InChI InChI=1S/C39H72O5/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-38(41)43-36-37(35-40)44-39(42)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h17-20,37,40H,3-16,21-36H2,1-2H3/b19-17-,20-18-
InChIKey AFSHUZFNMVJNKX-CLFAGFIQSA-N
SMILES CCCCCCCCC=CCCCCCCCC(=O)OCC(CO)OC(=O)CCCCCCCC=CCCCCCCCC
Reference

<span style="color:#000000;"><span style="font-size:12px;"><span style="font-family:arial,helvetica,sans-serif;">1.Yamaguchi, Yasuto, et al. &quot;Phosphorylation and up-regulation of diacylglycerol kinase &gamma; via its interaction with protein kinase C&gamma;.&quot;&nbsp;<i style="font-family: Arial, sans-serif; font-size: 13px;">Journal of Biological Chemistry</i>&nbsp;281.42 (2006): 31627-31637.<br />
2.Zhou, Qingzhong, et al. &quot;Structure-activity relationship of synthetic branched-chain distearoylglycerol (distearin) as protein kinase C activators.&quot;&nbsp;<i style="font-family: Arial, sans-serif; font-size: 13px;">Biochemistry</i>&nbsp;27.19 (1988): 7361-7365.<br />
3.Epand, Richard M., et al. &quot;Substrate chirality and specificity of diacylglycerol kinases and the multisubstrate lipid kinase.&quot;&nbsp;<i style="font-family: Arial, sans-serif; font-size: 13px;">Biochemistry</i>&nbsp;46.49 (2007): 14225-14231.</span></span></span>

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