116-9e

• CAT Number: I012493
• CAS Number: 831217-43-7
• Molecular Formula: C31H32N2O5
• Molecular Weight: 512.60
• Purity: ≥95%
• Synonyms: 6-[4-methyl-2-oxo-5-phenylmethoxycarbonyl-6-(4-phenylphenyl)-1,6-dihydropyrimidin-3-yl]hexanoic acid
• InChI: InChI=1S/C31H32N2O5/c1-22-28(30(36)38-21-23-11-5-2-6-12-23)29(32-31(37)33(22)20-10-4-9-15-27(34)35)26-18-16-25(17-19-26)24-13-7-3-8-14-24/h2-3,5-8,11-14,16-19,29H,4,9-10,15,20-21H2,1H3,(H,32,37)(H,34,35)
• InChIKey: GHFQWLNXJMUCGC-UHFFFAOYSA-N
• SMILES: CC1=C(C(NC(=O)N1CCCCCC(=O)O)C2=CC=C(C=C2)C3=CC=CC=C3)C(=O)OCC4=CC=CC=C4

116-9e (Cat No.: I012493) is a synthetic small-molecule inhibitor that selectively disrupts the interaction between Hsp70 (heat shock protein 70) and BAG domain co-chaperones, impairing protein folding and stability of oncogenic client proteins. By targeting this chaperone–cofactor interaction, 116-9e promotes proteotoxic stress and apoptosis in cancer cells. It has been used in preclinical studies to explore cancer biology, stress response pathways, and therapeutic strategies targeting protein homeostasis. 116-9e is a valuable research tool for studying molecular chaperones, cofactor regulation, and tumor progression mechanisms.

Reference

[1]. Christine M Wright, et al. Inhibition of Simian Virus 40 replication by targeting the molecular chaperone function and ATPase activity of T antigen. Virus Res. 2009 Apr;141(1):71-80.
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[2]. Nitika, et al. Chemogenomic screening identifies the Hsp70 co-chaperone DNAJA1 as a hub for anticancer drug resistance. Sci Rep. 2020 Aug 14;10(1):13831.
[Content Brief]