10058-F4

• CAT Number: I003466
• CAS Number: 403811-55-2
• Molecular Formula: C₁₂H₁₁NOS₂
• Molecular Weight: 249.35
• Purity: ≥95%
• Target: c-Myc
• Solubility: DMSO: ≥ 41 mg/mL
• Storage: 2-8°C
• IUPAC Name: (5E)-5-[(4-ethylphenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one
• InChI: InChI=1S/C12H11NOS2/c1-2-8-3-5-9(6-4-8)7-10-11(14)13-12(15)16-10/h3-7H,2H2,1H3,(H,13,14,15)/b10-7+
• InChIKey: SVXDHPADAXBMFB-JXMROGBWSA-N
• SMILES: CCC1=CC=C(C=C1)C=C2C(=O)NC(=S)S2

10058-F4（Cat No.:I003466） is a potent inhibitor of the c-Myc-Max interaction, effectively preventing the transcriptional activation of c-Myc target genes. By inhibiting c-Myc activity, 10058-F4 hampers cell proliferation and promotes apoptosis through the activation of Caspase-3. Additionally, it plays a role in regulating autophagy, the cellular process of self-degradation. Through its multifaceted actions, 10058-F4 exhibits potential therapeutic applications in diseases where c-Myc signaling is dysregulated, such as cancer, by targeting key pathways involved in cell survival and growth.

Reference

1:Inhibition of c-Myc by 10058-F4 induces growth arrest and chemosensitivity in pancreatic ductal adenocarcinoma. Zhang M, Fan HY, Li SC.Biomed Pharmacother. 2015 Jul;73:123-8. doi: 10.1016/j.biopha.2015.05.019. Epub 2015 Jun 1. PMID: 26211592 2:10058-F4, a c-Myc inhibitor, markedly increases valproic acid-induced cell death in Jurkat and CCRF-CEM T-lymphoblastic leukemia cells. Mu Q, Ma Q, Lu S, Zhang T, Yu M, Huang X, Chen J, Jin J.Oncol Lett. 2014 Sep;8(3):1355-1359. Epub 2014 Jun 24. PMID: 25120723 Free PMC Article3:Efficacy, pharmacokinetics, tisssue distribution, and metabolism of the Myc-Max disruptor, 10058-F4 [Z,E]-5-[4-ethylbenzylidine]-2-thioxothiazolidin-4-one, in mice. Guo J, Parise RA, Joseph E, Egorin MJ, Lazo JS, Prochownik EV, Eiseman JL.Cancer Chemother Pharmacol. 2009 Mar;63(4):615-25. doi: 10.1007/s00280-008-0774-y. Epub 2008 May 29. PMID: 18509642 Free PMC Article4:Small-molecule c-Myc inhibitor, 10058-F4, inhibits proliferation, downregulates human telomerase reverse transcriptase and enhances chemosensitivity in human hepatocellular carcinoma cells. Lin CP, Liu JD, Chow JM, Liu CR, Liu HE.Anticancer Drugs. 2007 Feb;18(2):161-70. PMID: 17159602 5:A small-molecule c-Myc inhibitor, 10058-F4, induces cell-cycle arrest, apoptosis, and myeloid differentiation of human acute myeloid leukemia. Huang MJ, Cheng YC, Liu CR, Lin S, Liu HE.Exp Hematol. 2006 Nov;34(11):1480-9. PMID: 17046567