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1-(3,3-Dimethyl-1,2-dioxopentyl)-L-proline 3-(3-pyridinyl)propyl Ester

1-(3,3-Dimethyl-1,2-dioxopentyl)-L-proline 3-(3-pyridinyl)propyl Ester

  • CAT Number: R041687
  • CAS Number: 186452-09-5
  • Molecular Formula: C20H28N2O4
  • Molecular Weight: 360.45
  • Purity: ≥95%
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GPI-1046（Cat No.:R041687） is an immunophilin ligand known for its ability to reduce ethanol intake by upregulating the expression of glutamate transporter 1 (GLT1) in the prefrontal cortex (PFC) and nucleus accumbens (NAc) core. It does not possess antibiotic properties. Being an analog of FK506, GPI-1046 exhibits neuroprotective effects in models of neurodegenerative diseases. It easily crosses the blood-brain barrier and promotes the regeneration of dopamine cells in the central nervous system, leading to functional recovery in rodent models. GPI-1046 has also shown improvements in HIV-associated peripheral nerve injury.

Catalog Number R041687
CAS Number 186452-09-5
Molecular Formula

C20H28N2O4

Purity 95%
Storage 2-8°C
IUPAC Name 3-pyridin-3-ylpropyl (2S)-1-(3,3-dimethyl-2-oxopentanoyl)pyrrolidine-2-carboxylate
InChI InChI=1S/C20H28N2O4/c1-4-20(2,3)17(23)18(24)22-12-6-10-16(22)19(25)26-13-7-9-15-8-5-11-21-14-15/h5,8,11,14,16H,4,6-7,9-10,12-13H2,1-3H3/t16-/m0/s1
InChIKey OQAHHWOPVDDWHD-INIZCTEOSA-N
SMILES CCC(C)(C)C(=O)C(=O)N1CCCC1C(=O)OCCCC2=CN=CC=C2

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