ζ-Stat trisodium

• CAT Number: I014806
• CAS Number: 31894-34-5
• Molecular Formula: C₁₀H₅Na₃O₁₀S₃
• Molecular Weight: 450.31
• Purity: ≥95%

ζ-Stat trisodium(CAT: I014806), also known as Zeta-Stat trisodium, is a compound that acts as a potent and selective inhibitor of the protein kinase ζ (PKζ), a member of the atypical protein kinase C (aPKC) family. It is a trisodium salt form of ζ-Stat. PKζ is involved in various cellular processes, including cell proliferation, survival, and migration, as well as synaptic plasticity and memory formation in the central nervous system. By inhibiting PKζ, ζ-Stat trisodium can modulate these cellular processes and potentially impact the development and progression of certain diseases. However, it’s important to note that information on the specific pharmacological activities, applications, and target information of ζ-Stat trisodium may be limited or evolving, as research in this area is ongoing.

Reference

[1]. Ratnayake WS, et, al. Oncogenic PKC-ι activates Vimentin during epithelial-mesenchymal transition in melanoma; a study based on PKC-ι and PKC-ζ specific inhibitors. Cell Adh Migr. 2018; 12(5):447-463.[2]. Islam SMA, et, al. Atypical Protein Kinase-C inhibitors exhibit a synergistic effect in facilitating DNA damaging effect of 5-fluorouracil in colorectal cancer cells. Biomed Pharmacother. 2020 Jan; 121:109665.