ζ-Stat

• CAT Number: I014807
• CAS Number: 3316-02-7
• Molecular Formula: C₁₀H₈O₁₀S₃
• Molecular Weight: 384.36
• Purity: ≥95%

ζ-Stat (CAT: I014807), also known as NSC37044, is a specific and atypical inhibitor of PKC-ζ (protein kinase C-zeta). It has an IC50 of 5 μM against PKC-ζ. ζ-Stat has demonstrated the ability to reduce proliferation and induce apoptosis in melanoma cell lines, showcasing potential antitumor activity in vitro. It shows limited inhibition on PKC-ι but exhibits significant inhibition on PKC-ζ. Treatment with ζ-Stat results in decreased cell proliferation in SK-MEL-2 and MeWo cells with increasing concentrations. Combining ζ-Stat with 5-FU has shown a synergistic effect in reducing the viability of LoVo CRC cells. ζ-Stat treatment also leads to a reduction in phosphorylated and total PKC-ζ, Bcl-2, and PARP levels, while increasing Caspase-3 and cleaved-PARP levels in melanoma cells

Reference

[1]. Ratnayake WS, et, al. Oncogenic PKC-ι activates Vimentin during epithelial-mesenchymal transition in melanoma; a study based on PKC-ι and PKC-ζ specific inhibitors. Cell Adh Migr. 2018; 12(5):447-463.[2]. Islam SMA, et, al. Atypical Protein Kinase-C inhibitors exhibit a synergistic effect in facilitating DNA damaging effect of 5-fluorouracil in colorectal cancer cells. Biomed Pharmacother. 2020 Jan; 121:109665.