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β-Estradiol-6-one 6-(O-carboxymethyloxime)

β-Estradiol-6-one 6-(O-carboxymethyloxime)

  • CAT Number: R042514
  • CAS Number: 35048-47-6
  • Molecular Formula: C₂₀H₂₅NO₅
  • Molecular Weight: 359.42
  • Purity: ≥95%
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<p>
<span style="color:#000000;"><span style="font-size:12px;"><span style="font-family:arial,helvetica,sans-serif;">&beta;-Estradiol-6-one 6-(O-carboxymethyloxime) (CAS&nbsp;35048-47-6)&nbsp;was shown to exhibit regulatory activities towards the expression of leptin, a protein hormone that coordinate appetite/hunger and metabolism.&beta;-Estradiol-6-one 6-(O-carboxymethyloxime) was shown to control the secretion of leptin via membrane associated estrogen receptor alpha in human placental cells.</span></span></span></p>

Catalog Number R042514
CAS Number 35048-47-6
Synonyms

2-[[[(17β)-3,17-Dihydroxyestra-1,3,5(10)-trien-6-ylidene]amino]oxy]acetic Acid; Estrane Acetic Acid Deriv.; 17β-Estradiol 6-(O-carboxymethyl)oxime; 6-Oxo-17β-estradiol 6-[O-(carboxymethyl)oxime]; 6-Oxoestradiol (carboxymethyl)oxime; Estradiol 6-(O-ca

Molecular Formula

C₂₀H₂₅NO₅

Purity 95%
Storage Desiccate at RT
IUPAC Name 2-[(Z)-[(8R,9S,13S,14S,17S)-3,17-dihydroxy-13-methyl-8,9,11,12,14,15,16,17-octahydro-7H-cyclopenta[a]phenanthren-6-ylidene]amino]oxyacetic acid
InChI InChI=1S/C20H25NO5/c1-20-7-6-13-12-3-2-11(22)8-15(12)17(21-26-10-19(24)25)9-14(13)16(20)4-5-18(20)23/h2-3,8,13-14,16,18,22-23H,4-7,9-10H2,1H3,(H,24,25)/b21-17-/t13-,14-,16+,18+,20+/m1/s1
InChIKey AWARIMYXKAIIGO-UYGYUSPXSA-N
SMILES CC12CCC3C(C1CCC2O)CC(=NOCC(=O)O)C4=C3C=CC(=C4)O
Reference

<p>
<span style="color:#000000;"><span style="font-size:12px;"><span style="font-family:arial,helvetica,sans-serif;">1.Gambino, Y&eacute;sica P., et al. &quot;Regulation of leptin expression by 17beta-estradiol in human placental cells involves membrane associated estrogen receptor alpha.&quot;&nbsp;<i style="font-family: Arial, sans-serif; font-size: 13px;">Biochimica et Biophysica Acta (BBA)-Molecular Cell Research</i>&nbsp;1823.4 (2012): 900-910.<br />
2.Somjen, Dalia, et al. &quot;Dihydrotestosterone and estradiol-17&beta; mutually neutralize their inhibitory effects on human vascular smooth muscle cell growth in vitro.&quot;&nbsp;<i style="font-family: Arial, sans-serif; font-size: 13px;">The Journal of steroid biochemistry and molecular biology</i>&nbsp;113.3-5 (2009): 171-176.<br />
3.Arreguin-Arevalo, J. Alejandro, and Terry M. Nett. &quot;A nongenomic action of estradiol as the mechanism underlying the acute suppression of secretion of luteinizing hormone in ovariectomized ewes.&quot;&nbsp;<i style="font-family: Arial, sans-serif; font-size: 13px;">Biology of reproduction</i>&nbsp;74.1 (2006): 202-208.</span></span></span></p>

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