α-Methyl-L-tyrosine

• CAT Number: R000665
• CAS Number: 672-87-7
• Molecular Formula: C10H13NO3
• Molecular Weight: 195.218
• Purity: ≥95%
• Storage: Store at RT
• IUPAC Name: (2S)-2-amino-3-(4-hydroxyphenyl)-2-methylpropanoic acid
• InChI: InChI=1S/C10H13NO3/c1-10(11,9(13)14)6-7-2-4-8(12)5-3-7/h2-5,12H,6,11H2,1H3,(H,13,14)/t10-/m0/s1
• InChIKey: NHTGHBARYWONDQ-JTQLQIEISA-N
• SMILES: CC(CC1=CC=C(C=C1)O)(C(=O)O)N

Metyrosine is an inhibitor of the enzyme TYROSINE 3-MONOOXYGENASE, and consequently of the synthesis of catecholamines. It is used to control the symptoms of excessive sympathetic stimulation in patients with PHEOCHROMOCYTOMA. Metyrosine competitively inhibits tyrosine 3-monooxygenase, an enzyme that activates molecular oxygen to catalyze the hydroxylation of tyrosine to dihydroxyphenylalanine (Dopa), an intermediate to catecholamine (dopamine, norepinephrine, and epinephrine) production. This agent reduces the elevated levels of catecholamines associated with pheochromocytoma, thereby preventing hypertension.

Reference

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