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α-Mangostin

α-Mangostin

  • CAT Number: R009141
  • CAS Number: 6147-11-1
  • Molecular Formula: C₂₄H₂₆O₆
  • Molecular Weight: 410.46
  • Purity: ≥95%
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Alpha-Mangostin is a natural xanthonoid, a type of organic compound isolated from various parts of the mangosteen tree (Garcinia mangostana). It is a yellow crystalline solid with a xanthone core structure. Mangostin and a variety of other xanthones from mangosteen have been investigated for biological properties including antioxidant, anti-bacterial, anti-inflammatory, and anticancer activities. α-Mangostin Induces Apoptosis and Cell Cycle Arrest in Oral Squamous Cell Carcinoma Cell. Alpha-mangostin attenuates brain inflammation induced by peripheral lipopolysaccharide administration in C57BL/6J mice. α-Mangostin Inhibits α-Synuclein-Induced Microglial Neuroinflammation and Neurotoxicity.

Catalog Number R009141
CAS Number 6147-11-1
Synonyms

1,3,6-Trihydroxy-7-methoxy-2,8-bis(3-methyl-2-buten-1-yl)-9H-xanthen-9-one; ?1,3,6-Trihydroxy-7-methoxy-2,8-bis(3,3-dimethylallyl)xanthone; α-Mangosten; ?α-Mangostin; NSC 139154; NSC 27593; NSC 30552;?

Molecular Formula

C₂₄H₂₆O₆

Purity 95%
Storage -20°C
InChI InChI=1S/C24H26O6/c1-12(2)6-8-14-16(25)10-19-21(22(14)27)23(28)20-15(9-7-13(3)4)24(29-5)17(26)11-18(20)30-19/h6-7,10-11,25-27H,8-9H2,1-5H3
InChIKey GNRIZKKCNOBBMO-UHFFFAOYSA-N
SMILES CC(=CCC1=C(C=C2C(=C1O)C(=O)C3=C(C(=C(C=C3O2)O)OC)CC=C(C)C)O)C
Reference

</br>1:In Vitro and In Vivo Inhibitory Effects of α-Mangostin on Cholangiocarcinoma Cells and Allografts Aukkanimart R, Boonmars T, Sriraj P, Sripan P, Songsri J, Ratanasuwan P, Laummaunwai P, Boueroy P, Khueangchaingkhwang S, Pumhirunroj B, Artchayasawat A, Boonjaraspinyo S, Wu Zh, Hahnvajanawong Ch, Vaeteewoottacharn K, Wongkham S.Asian Pac J Cancer Prev. 2017 Mar 1;18(3):707-713. PMID: 28441703 Free Article</br>2:α-Mangostin decreases β-amyloid peptides production via modulation of amyloidogenic pathway. Zhao LX, Wang Y, Liu T, Wang YX, Chen HZ, Xu JR, Qiu Y.CNS Neurosci Ther. 2017 Apr 21. doi: 10.1111/cns.12699. [Epub ahead of print] PMID: 28429536 </br>3:In vitro activity of alpha-mangostin in killing and eradicating Staphylococcus epidermidis RP62A biofilms. Sivaranjani M, Prakash M, Gowrishankar S, Rathna J, Pandian SK, Ravi AV.Appl Microbiol Biotechnol. 2017 Apr;101(8):3349-3359. doi: 10.1007/s00253-017-8231-7. Epub 2017 Mar 25. PMID: 28343241 </br>4:Development and in vivo evaluation of self-microemulsion as delivery system for α-mangostin. Xu WK, Jiang H, Yang K, Wang YQ, Zhang Q, Zuo J.Kaohsiung J Med Sci. 2017 Mar;33(3):116-123. doi: 10.1016/j.kjms.2016.12.003. Epub 2017 Jan 12. PMID: 28254113 Free Article</br>5:Anti-Bacterial and Anti-Fungal Activity of Xanthones Obtained via Semi-Synthetic Modification of α-Mangostin from Garcinia mangostana. Narasimhan S, Maheshwaran S, Abu-Yousef IA, Majdalawieh AF, Rethavathi J, Das PE, Poltronieri P.Molecules. 2017 Feb 12;22(2). pii: E275. doi: 10.3390/molecules22020275. PMID: 28208680 Free Article</br>6:Synergic Effect of <i>α</i>-Mangostin on the Cytotoxicity of Cisplatin in a Cervical Cancer Model. Pérez-Rojas JM, González-Macías R, González-Cortes J, Jurado R, Pedraza-Chaverri J, García-López P.Oxid Med Cell Longev. 2016;2016:7981397. doi: 10.1155/2016/7981397. Epub 2016 Dec 8. PMID: 28053694 Free PMC Article</br>7:Alpha-mangostin from mangosteen (<i>Garcinia mangostana Linn.)</i> pericarp extract reduces high fat-diet induced hepatic steatosis in rats by regulating mitochondria function and apoptosis. Tsai SY, Chung PC, Owaga EE, Tsai IJ, Wang PY, Tsai JI, Yeh TS, Hsieh RH.Nutr Metab (Lond). 2016 Dec 1;13:88. eCollection 2016. PMID: 27980597 Free PMC Article</br>8:In Vitro Permeation and Skin Retention of α-Mangostin Proniosome. Chin GS, Todo H, Kadhum WR, Hamid MA, Sugibayashi K.Chem Pharm Bull (Tokyo). 2016;64(12):1666-1673. PMID: 27904075 Free Article</br>9:Anticarcinogenic Effects of α-Mangostin: A Review. Zhang KJ, Gu QL, Yang K, Ming XJ, Wang JX.Planta Med. 2017 Feb;83(3-04):188-202. doi: 10.1055/s-0042-119651. Epub 2016 Nov 4. PMID: 27824406 </br>10:Sensitization of 5-Fluorouracil-Resistant SNUC5 Colon Cancer Cells to Apoptosis by α-Mangostin. Lee J, Kang JS, Choi BY, Keum YS.Biomol Ther (Seoul). 2016 Nov 1;24(6):604-609. doi: 10.4062/biomolther.2016.028. PMID: 27469143 Free PMC Article

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