(±)14(15)DiHET-d11

• CAT Number: R019971
• Molecular Formula: C20H23D11O4
• Molecular Weight: 349.6
• Purity: ≥95%
• Synonyms: (±)14,15-DiHETrE-d11
• Storage: -20°C
• InChI: InChI=1S/C20H34O4/c1-2-3-12-15-18(21)19(22)16-13-10-8-6-4-5-7-9-11-14-17-20(23)24/h4,6-7,9-10,13,18-19,21-22H,2-3,5,8,11-12,14-17H2,1H3,(H,23,24)/b6-4-,9-7-,13-10-/t18-,19+/m1/s1/i1D3,2D2,3D2,12D2,15D2
• InChIKey: SYAWGTIVOGUZMM-LAOIBNNJSA-N
• SMILES: O[C@H]([C@H](O)C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H])C/C=CC/C=CC/C=CCCCC(O)=O

(±)14(15)-<wbr></wbr>DiHET-<wbr></wbr>d11 contains 11 deuterium atoms at the 16, 16, 17, 17, 18, 18, 19, 19, 20, 20, and 20 positions. It is intended for use as an internal standard for the quantification of (±)14(15)-<wbr></wbr>DiHET (Item No. 51651) by GC-<wbr></wbr> or LC-<wbr></wbr>mass spectrometry. Epoxide hydrolases convert the EETs into vicinal diols, with the concurrent loss of much of their biological activity. (±)14(15)-<wbr></wbr>DiHET is the urinary metabolite of (±)14(15)-<wbr></wbr>EET (Item No. 50651) which has been documented by GC-<wbr></wbr>MS to be elevated in pregnancy-<wbr></wbr>induced hypertension.

Reference

1.Oliw, E.H.,Guengerich, F.P., and Oates, J.A. Oxygenation of arachidonic acid by hepatic monooxygenases. Isolation and metabolism of four epoxide intermediates. The Journal of Biological Chemisty 257, 3771-3781 (1982).