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GN39482 CAS:

Category: Inhibitors
Product Name: GN39482
Cat No: I006990
CAS No:
Synonyms: None
Molecular Formula: C19H17N3O3
Molecular Weight: 335.36
SMILES: O=C(OC)C1=CC=CC(NC2=NNC3=C2CC4=C3C=CC(OC)=C4)=C1
InChI: None
InChIKey: None
Solubility: Soluble in DMSO, not in water
Target: Tubulin Polymerization Inhibitor
CAS ,GN39482
  • Description

GN39482 is a tubulin polymerization inhibitor, which was identified by MorphoBase and ChemProteoBase profiling methods. GN39482 possesses a promising antiproliferative activity toward human cancer cells without affecting any antimicrobial and antimalarial activities at 100 nM. GN39482 inhibited the acetylated tubulin accumulation and the microtubule formation and induced G2/M cell cycle arrest in HeLa cells, revealing that a promising antiproliferative activity of compound 6m toward human cancer cells is probably caused by the tubulin polymerization inhibition.

  • Spec

Appearance:Solid powder
Purity: > 98%

  • References

1:J Med Chem. 2015 May 28;58(10):4230-41. doi: 10.1021/acs.jmedchem.5b00035. Epub 2015 May 11. Methyl 3-((6-methoxy-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)amino)benzoate (GN39482) as a tubulin polymerization inhibitor identified by MorphoBase and ChemProteoBase profiling methods.Minegishi H,Futamura Y,Fukashiro S,Muroi M,Kawatani M,Osada H,Nakamura H, PMID: 25938266 DOI: 10.1021/acs.jmedchem.5b00035
Abstract: A series of indenopyrazoles was synthesized from the corresponding indanones and phenyl isothiocyanates in two steps. Among the compounds synthesized, methyl 3-((6-methoxy-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)amino)benzoate 6m (GN39482) was found to possess a promising antiproliferative activity toward human cancer cells without affecting any antimicrobial and antimalarial activities at 100 nM. Both a methoxy group at R(1) position and a methoxycarbonyl group at R(2) position of the anilinoquinazoline framework are essential for the high cell growth inhibition. Both MorphoBase and ChemProteoBase profiling analyses suggested that compound 6m was classified as a tubulin inhibitor. Indeed, compound 6m inhibited the acetylated tubulin accumulation and the microtubule formation and induced G2/M cell cycle arrest in HeLa cells, revealing that a promising antiproliferative activity of compound 6m toward human cancer cells is probably caused by the tubulin polymerization inhibition.


price inquiry for CAS:, Product:GN39482