This receptor is non-specific for endothelin 1, 2, and 3 and mediates their actions by associating with G proteins. Upon activation, it triggers a phosphatidylinositol-calcium second messenger system. This signaling pathway plays a key role in various cellular processes, including vascular tone regulation and smooth muscle contraction. The receptor’s ability to interact with multiple endothelins allows it to contribute to a wide range of physiological responses, influencing blood pressure regulation, cellular growth, and other important functions in response to endothelin signaling.
| Product Name | Recombinant Human Endothelin B Receptor (EDNRB) Protein (His), Active |
| Accession | P24530 |
| Purity | Greater than 90% as determined by SDS-PAGE. |
| Host Species | Homo sapiens (Human) |
| Gene | EDNRB |
| Source | in vitro E.coli expression system |
| Protein Expression Range | 27-442aa |
| Tag | C-10His |
| Molecular Mass | 50.3kDa |
| Form | Liquid or Lyophilized powder |
| Buffer | Liquid form: default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0. |
| Storage | 1. Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. 2. Avoid repeated freeze-thaw cycles. 3. Store working aliquots at 4°C for up to one week. 4. In general, protein in liquid form is stable for up to 6 months at -20°C/-80°C. Protein in lyophilized powder form is stable for up to 12 months at -20°C/-80°C. |
| Bioactivity | Active |
