This protein plays a key role in alveolar fluid homeostasis by regulating the composition of alveolar epithelial tight junctions, influencing ion transport and solute permeability, potentially through downstream effects on actin cytoskeleton organization and beta-2-adrenergic signaling. It is essential for lung alveolarization and maintaining the paracellular alveolar epithelial barrier. It also supports epithelial progenitor cell proliferation and organ size by controlling YAP1 localization, limiting YAP1 target gene transcription. Additionally, it negatively regulates RANKL-induced osteoclast differentiation, contributing to bone resorption in calcium deficiency, and mediates the osteoprotective effects of estrogen, potentially independent of RANKL signaling.
| Product Name | Recombinant Human Claudin-18 (CLDN18) Protein (GST) |
| Accession | P56856 |
| Purity | Greater than 85% as determined by SDS-PAGE. |
| Host Species | Homo sapiens (Human) |
| Gene | CLDN18 |
| Source | E.coli |
| Protein Expression Range | 28-80aa |
| Tag | N-GST |
| Molecular Mass | 32.8 kDa |
| Form | Liquid or Lyophilized powder |
| Buffer | Liquid form: default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0. |
| Storage | 1. Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. 2. Avoid repeated freeze-thaw cycles. 3. Store working aliquots at 4°C for up to one week. 4. In general, protein in liquid form is stable for up to 6 months at -20°C/-80°C. Protein in lyophilized powder form is stable for up to 12 months at -20°C/-80°C. |
