ZZL-7

• CAT Number: I042482
• CAS Number: 99141-91-0
• Molecular Formula: C11H20N2O4
• Molecular Weight: 244.29
• Purity: ≥95%
• Synonyms: methyl (2S)-2-[[(2S)-2-acetamidopropanoyl]amino]-3-methylbutanoate
• InChI: InChI=1S/C11H20N2O4/c1-6(2)9(11(16)17-5)13-10(15)7(3)12-8(4)14/h6-7,9H,1-5H3,(H,12,14)(H,13,15)/t7-,9-/m0/s1
• InChIKey: RHDUVXUSBMPQOK-CBAPKCEASA-N
• SMILES: CC(C)C(C(=O)OC)NC(=O)C(C)NC(=O)C

ZZL-7 (Cat No.: I042482) is a synthetic small-molecule inhibitor designed to target and inhibit SIRT2, a member of the sirtuin family of NAD⁺-dependent deacetylases. SIRT2 is implicated in cellular processes such as aging, inflammation, and tumorigenesis. By selectively inhibiting SIRT2, ZZL-7 shows potential in modulating neurodegenerative diseases like Parkinson’s and Huntington’s, as well as certain cancers. Preclinical studies suggest that ZZL-7 can restore normal acetylation levels of target proteins, offering therapeutic promise in diseases where SIRT2 is dysregulated. Further research is ongoing.

Reference

[1]. Nan Sun, et al. Design of fast-onset antidepressant by dissociating SERT from nNOS in the DRN. Science. 2022 Oct 28;378(6618):390-398.
[Content Brief]