ZW4864

• CAT Number: I045385
• CAS Number: 2632259-93-7
• Molecular Formula: C33H43ClN6O3
• Molecular Weight: 607.19
• Purity: ≥95%
• Synonyms: (3R)-N-cyclopropyl-1-[3-(2-methyl-1-oxo-1-piperazin-4-ium-1-ylpropan-2-yl)oxyphenyl]-N-[[4-(1H-pyrazol-4-yl)phenyl]methyl]piperidine-3-carboxamide;chloride
• InChI: InChI=1S/C33H42N6O3.ClH/c1-33(2,32(41)37-17-14-34-15-18-37)42-30-7-3-6-29(19-30)38-16-4-5-26(23-38)31(40)39(28-12-13-28)22-24-8-10-25(11-9-24)27-20-35-36-21-27;/h3,6-11,19-21,26,28,34H,4-5,12-18,22-23H2,1-2H3,(H,35,36);1H/t26-;/m1./s1
• InChIKey: PQRRIGABHUYXRQ-UFTMZEDQSA-N
• SMILES: CC(C)(C(=O)N1CC[NH2+]CC1)OC2=CC=CC(=C2)N3CCCC(C3)C(=O)N(CC4=CC=C(C=C4)C5=CNN=C5)C6CC6.[Cl-]

ZW4864 (Cat No.: I045385) is a selective small-molecule inhibitor targeting enhancer of zeste homolog 2 (EZH2), a histone methyltransferase involved in epigenetic gene silencing through trimethylation of histone H3 at lysine 27 (H3K27me3). Overexpression or mutation of EZH2 is implicated in various cancers, including lymphomas and solid tumors. By inhibiting EZH2 activity, ZW4864 reactivates tumor suppressor genes and impairs cancer cell proliferation. It is primarily used in preclinical studies to investigate epigenetic regulation and evaluate targeted cancer therapies involving EZH2 inhibition.

Reference

[1]. Wang Z, et al. Discovery of an Orally Bioavailable Small-Molecule Inhibitor for the β-Catenin/B-Cell Lymphoma 9 Protein-Protein Interaction. J Med Chem. 2021;64(16):12109-12131.
[Content Brief]