For research use only. Not for therapeutic Use.
Zotizalkib (Cat No.:I044430) is a selective small-molecule inhibitor of STAT3 (Signal Transducer and Activator of Transcription 3), a transcription factor frequently dysregulated in cancer and inflammatory diseases. By blocking STAT3 phosphorylation and dimerization, zotizalkib inhibits its nuclear translocation and transcriptional activity, suppressing genes involved in cell proliferation, survival, angiogenesis, and immune evasion. It has shown promising antitumor and anti-inflammatory effects in preclinical and early clinical studies. Zotizalkib is being explored as a targeted therapy in solid tumors and hematologic malignancies where aberrant STAT3 signaling drives disease progression.
| CAS Number | 2648641-36-3 |
| Synonyms | (18S)-18-(difluoromethyl)-13-fluoro-7,7-dimethyl-9,20-dioxa-1,2,6,17,23-pentazapentacyclo[19.3.1.04,24.010,15.017,22]pentacosa-2,4(24),10(15),11,13,21(25),22-heptaen-5-one |
| Molecular Formula | C21H20F3N5O3 |
| Purity | ≥95% |
| IUPAC Name | (18S)-18-(difluoromethyl)-13-fluoro-7,7-dimethyl-9,20-dioxa-1,2,6,17,23-pentazapentacyclo[19.3.1.04,24.010,15.017,22]pentacosa-2,4(24),10(15),11,13,21(25),22-heptaen-5-one |
| InChI | InChI=1S/C21H20F3N5O3/c1-21(2)10-32-15-4-3-12(22)5-11(15)7-28-14(17(23)24)9-31-16-8-29-18(26-19(16)28)13(6-25-29)20(30)27-21/h3-6,8,14,17H,7,9-10H2,1-2H3,(H,27,30)/t14-/m0/s1 |
| InChIKey | ILAMRXVQSGVCJX-AWEZNQCLSA-N |
| SMILES | CC1(COC2=C(CN3[C@@H](COC4=CN5C(=C(C=N5)C(=O)N1)N=C43)C(F)F)C=C(C=C2)F)C |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
