For research use only. Not for therapeutic Use.
ZK159222(CAT:R043363） is a 25-carboxylic ester analogue of 1α,25-dihydroxyvitamin D₃ (1α,25-(OH)₂D₃) and functions as a potent vitamin D receptor (VDR) antagonist with partial agonistic properties. Its antagonistic activity is attributed to impaired ligand-induced VDR–coactivator interaction. ZK159222 displays weak agonist activity, requiring ~7-fold higher concentrations than 1α,25-(OH)₂D₃ to stabilize VDR–RXR heterodimer complexes on DR3-type VDREs. Notably, it induces a unique third VDR conformation, similar to some 20-epi analogues. When combined with 1α,25-(OH)₂D₃, ZK159222 reduces transcriptional activity while retaining partial agonist function, making it a valuable tool for studying vitamin D signaling, receptor conformations, and transcriptional regulation.
| CAS Number | 156965-15-0 |
| Synonyms | butyl 1-[(E,1R,4R)-4-[(1R,3aS,4E,7aR)-4-[(2Z)-2-[(3S,5R)-3,5-dihydroxy-2-methylidenecyclohexylidene]ethylidene]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-1-yl]-1-hydroxypent-2-enyl]cyclopropane-1-carboxylate |
| Molecular Formula | C32H48O5 |
| Purity | ≥95% |
| IUPAC Name | butyl 1-[(E,1R,4R)-4-[(1R,3aS,4E,7aR)-4-[(2Z)-2-[(3S,5R)-3,5-dihydroxy-2-methylidenecyclohexylidene]ethylidene]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-1-yl]-1-hydroxypent-2-enyl]cyclopropane-1-carboxylate |
| InChI | InChI=1S/C32H48O5/c1-5-6-18-37-30(36)32(16-17-32)29(35)14-9-21(2)26-12-13-27-23(8-7-15-31(26,27)4)10-11-24-19-25(33)20-28(34)22(24)3/h9-11,14,21,25-29,33-35H,3,5-8,12-13,15-20H2,1-2,4H3/b14-9+,23-10+,24-11-/t21-,25-,26-,27+,28+,29-,31-/m1/s1 |
| InChIKey | SPARTCPUGRJFRS-PBDCIXLPSA-N |
| SMILES | CCCCOC(=O)C1(CC1)C(C=CC(C)C2CCC3C2(CCCC3=CC=C4CC(CC(C4=C)O)O)C)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
