For research use only. Not for therapeutic Use.
ZINC49534341(CAT: I040527) is a potent and selective antagonist of the Mas-related G protein–coupled receptor X2 (MRGPRX2), exhibiting a binding affinity with a Ki of 32 nM. MRGPRX2 is predominantly expressed in mast cells and plays a key role in non-IgE-mediated pseudo-allergic and inflammatory responses. By blocking MRGPRX2 activity, ZINC49534341 effectively inhibits mast cell degranulation and downstream release of histamine and other pro-inflammatory mediators. This compound is a valuable research tool for studying mast cell-driven hypersensitivity, neurogenic inflammation, and related immune disorders. Suitable for in vitro and in vivo applications exploring novel anti-inflammatory and anti-allergic therapeutic strategies.
| CAS Number | 1274013-03-4 |
| Synonyms | 2-sulfanylidene-3-(1,3-thiazol-2-ylmethyl)-1H-quinazolin-4-one |
| Molecular Formula | C12H9N3OS2 |
| Purity | ≥95% |
| IUPAC Name | 2-sulfanylidene-3-(1,3-thiazol-2-ylmethyl)-1H-quinazolin-4-one |
| InChI | InChI=1S/C12H9N3OS2/c16-11-8-3-1-2-4-9(8)14-12(17)15(11)7-10-13-5-6-18-10/h1-6H,7H2,(H,14,17) |
| InChIKey | KGOOTXSIHAFXQU-UHFFFAOYSA-N |
| SMILES | C1=CC=C2C(=C1)C(=O)N(C(=S)N2)CC3=NC=CS3 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
