For research use only. Not for therapeutic Use.
Zifanocycline (KBP-7072) TFA(CAT: I040327) is an orally active, semi-synthetic aminomethylcycline antibiotic that exerts its antibacterial effect by inhibiting protein synthesis through binding to the 30S ribosomal subunit. As a next-generation tetracycline derivative, it exhibits broad-spectrum in vitro activity against both Gram-positive and Gram-negative pathogens, including multidrug-resistant strains such as MRSA, VRE, and ESBL-producing bacteria. Zifanocycline TFA is under investigation for the treatment of acute bacterial skin and skin structure infections (ABSSSI), community-acquired bacterial pneumonia (CABP), and complicated intra-abdominal infections (cIAI). It offers a promising tool for antimicrobial resistance research and infectious disease modeling.
| Synonyms | (4S,4aS,5aR,12aR)-9-(3-azabicyclo[3.1.0]hexan-3-ylmethyl)-4,7-bis(dimethylamino)-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide;2,2,2-trifluoroacetic acid |
| Molecular Formula | C31H37F3N4O9 |
| Purity | ≥95% |
| IUPAC Name | (4S,4aS,5aR,12aR)-9-(3-azabicyclo[3.1.0]hexan-3-ylmethyl)-4,7-bis(dimethylamino)-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide;2,2,2-trifluoroacetic acid |
| InChI | InChI=1S/C29H36N4O7.C2HF3O2/c1-31(2)18-8-15(11-33-9-13-5-14(13)10-33)23(34)20-16(18)6-12-7-17-22(32(3)4)25(36)21(28(30)39)27(38)29(17,40)26(37)19(12)24(20)35;3-2(4,5)1(6)7/h8,12-14,17,22,34-35,38,40H,5-7,9-11H2,1-4H3,(H2,30,39);(H,6,7)/t12-,13?,14?,17-,22-,29-;/m0./s1 |
| InChIKey | GYVCTUQXDLSCNC-LAYBQELUSA-N |
| SMILES | CN(C)C1C2CC3CC4=C(C=C(C(=C4C(=C3C(=O)C2(C(=C(C1=O)C(=O)N)O)O)O)O)CN5CC6CC6C5)N(C)C.C(=O)(C(F)(F)F)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
