Ziconotide acetate（Cat No.:I044776）is a synthetic peptide analog of ω-conotoxin MVIIA, originally derived from the venom of the marine cone snail Conus magus. It selectively blocks N-type voltage-gated calcium channels (Cav2.2) on neurons, inhibiting neurotransmitter release and providing potent analgesic effects. Ziconotide is approved for the treatment of severe chronic pain, particularly in patients unresponsive to conventional therapies, and is administered intrathecally. Supplied as an acetate salt for stability, ziconotide is also studied in neurobiology and pain research for its non-opioid mechanism, offering a novel approach to pain management without addiction risk.