For research use only. Not for therapeutic Use.
ZDLD20（Cat No.:I043935）is an orally active, selective β-carboline-based inhibitor of cyclin-dependent kinase 4 (CDK4)/Cyclin D3, exhibiting an IC₅₀ of 6.51 μM . It demonstrates potent anticancer activity against HCT116 colorectal cancer cells by inhibiting colony formation, suppressing invasion and migration, inducing apoptosis, and arresting the cell cycle at the G1 phase . Developed by Shenyang Pharmaceutical University, ZDLD20 is currently in preclinical development for cancer therapy . Its favorable predicted ADME and physicochemical properties make it a promising candidate for further optimization and preclinical evaluation .
| CAS Number | 2762279-02-5 |
| Synonyms | N-[5-(4-methylpiperazin-1-yl)pyridin-2-yl]-9H-pyrido[3,4-b]indole-1-carboxamide |
| Molecular Formula | C22H22N6O |
| Purity | ≥95% |
| IUPAC Name | N-[5-(4-methylpiperazin-1-yl)pyridin-2-yl]-9H-pyrido[3,4-b]indole-1-carboxamide |
| InChI | InChI=1S/C22H22N6O/c1-27-10-12-28(13-11-27)15-6-7-19(24-14-15)26-22(29)21-20-17(8-9-23-21)16-4-2-3-5-18(16)25-20/h2-9,14,25H,10-13H2,1H3,(H,24,26,29) |
| InChIKey | KNMQEDYCAKYYTK-UHFFFAOYSA-N |
| SMILES | CN1CCN(CC1)C2=CN=C(C=C2)NC(=O)C3=NC=CC4=C3NC5=CC=CC=C45 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
