For research use only. Not for therapeutic Use.
ZD7288（Cat No.:R056868）is a selective blocker of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, primarily affecting the I<sub>f</sub> (funny) current in cardiac pacemaker cells and I<sub>h</sub> currents in neurons. With the molecular formula C₁3H2₁ClN4, it is commonly used in electrophysiological and neurophysiological research to study the role of HCN channels in heart rate regulation, neuronal excitability, and rhythmic activity. ZD7288 inhibits spontaneous firing without significantly affecting other ion channels, making it a valuable tool in dissecting pacemaking mechanisms. It is not used therapeutically but is vital for understanding HCN channel function in health and disease.
| CAS Number | 133059-99-1 |
| Synonyms | N-ethyl-1,2-dimethyl-6-methylimino-N-phenylpyrimidin-4-amine;hydrochloride |
| Molecular Formula | C15H21ClN4 |
| Purity | ≥95% |
| IUPAC Name | N-ethyl-1,2-dimethyl-6-methylimino-N-phenylpyrimidin-4-amine;hydrochloride |
| InChI | InChI=1S/C15H20N4.ClH/c1-5-19(13-9-7-6-8-10-13)15-11-14(16-3)18(4)12(2)17-15;/h6-11H,5H2,1-4H3;1H |
| InChIKey | DUWKUHWHTPRMAP-UHFFFAOYSA-N |
| SMILES | CCN(C1=CC=CC=C1)C2=CC(=NC)N(C(=N2)C)C.Cl |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
