For research use only. Not for therapeutic Use.
ZC0109 (Cat No.: I042379) is a synthetic small molecule compound under investigation for its anti-inflammatory and immunomodulatory properties. It functions primarily as an inhibitor of TLR4 (Toll-like receptor 4), a key receptor involved in innate immune responses and inflammation. By blocking TLR4 signaling, ZC0109 may reduce the production of pro-inflammatory cytokines, offering potential therapeutic benefits in conditions such as sepsis, autoimmune diseases, and chronic inflammatory disorders. Preclinical studies suggest promising efficacy and safety, positioning ZC0109 as a candidate for further pharmaceutical development.
| Synonyms | N-[5-[3-[[4-[N’-(3-bromo-4-fluorophenyl)-N-hydroxycarbamimidoyl]-1,2,5-oxadiazol-3-yl]amino]propyl]-1,3,4-thiadiazol-2-yl]-2-(4-hydroxyphenyl)acetamide |
| Molecular Formula | C22H20BrFN8O4S |
| Purity | ≥95% |
| InChI | InChI=1S/C22H20BrFN8O4S/c23-15-11-13(5-8-16(15)24)26-21(30-35)19-20(32-36-31-19)25-9-1-2-18-28-29-22(37-18)27-17(34)10-12-3-6-14(33)7-4-12/h3-8,11,33,35H,1-2,9-10H2,(H,25,32)(H,26,30)(H,27,29,34) |
| InChIKey | UEYJCFRMVBBVMR-UHFFFAOYSA-N |
| SMILES | C1=CC(=CC=C1CC(=O)NC2=NN=C(S2)CCCNC3=NON=C3C(=NC4=CC(=C(C=C4)F)Br)NO)O |
| Reference | [1]. Zhou J, et al. Discovery of novel hydroxyamidine based indoleamine 2,3-dioxygenase 1 (IDO1) and thioredoxin reductase 1 (TrxR1) dual inhibitors. Eur J Med Chem. 2023 Jan 5;245(Pt 1):114860. |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
