For research use only. Not for therapeutic Use.
ZAP-180013（Cat No.:I015242）is a potent small-molecule inhibitor targeting zeta-associated protein 70 (ZAP-70), a tyrosine kinase essential for T-cell receptor (TCR) signaling and immune activation. By blocking ZAP-70 activity, ZAP-180013 suppresses downstream pathways including calcium mobilization, MAPK signaling, and NF-κB activation. This modulation makes it a valuable tool for studying autoimmunity, inflammation, and T-cell–mediated diseases. ZAP-180013 is widely used in immunology and pharmacological research to dissect TCR signaling mechanisms and evaluate kinase inhibition as a strategy for therapeutic immune modulation.
| CAS Number | 873080-25-2 |
| Synonyms | 5-chloro-N-[(4-chlorophenyl)methyl]-2-ethylsulfonyl-N-(furan-2-ylmethyl)pyrimidine-4-carboxamide |
| Molecular Formula | C19H17Cl2N3O4S |
| Purity | ≥95% |
| IUPAC Name | 5-chloro-N-[(4-chlorophenyl)methyl]-2-ethylsulfonyl-N-(furan-2-ylmethyl)pyrimidine-4-carboxamide |
| InChI | InChI=1S/C19H17Cl2N3O4S/c1-2-29(26,27)19-22-10-16(21)17(23-19)18(25)24(12-15-4-3-9-28-15)11-13-5-7-14(20)8-6-13/h3-10H,2,11-12H2,1H3 |
| InChIKey | GTWKIPDKVRLUKN-UHFFFAOYSA-N |
| SMILES | CCS(=O)(=O)C1=NC=C(C(=N1)C(=O)N(CC2=CC=C(C=C2)Cl)CC3=CC=CO3)Cl |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
