For research use only. Not for therapeutic Use.
Zagociguat（Cat No.:I045087）is an investigational oral stimulator of soluble guanylate cyclase (sGC), a key enzyme in the nitric oxide (NO) signaling pathway. By enhancing sGC activity, Zagociguat boosts cyclic GMP levels, leading to vasodilation, improved blood flow, and neurovascular benefits. It is being studied for the treatment of central nervous system disorders, including cognitive impairment and neurodegeneration. Zagociguat crosses the blood-brain barrier and may modulate neuroinflammation and synaptic function. Its potential spans conditions like Alzheimer’s disease and vascular dementia. Provided for research into NO-sGC-cGMP pathway modulation and neurotherapeutics.
| CAS Number | 2201048-82-8 |
| Synonyms | 8-[(2-fluorophenyl)methyl]-6-[5-(trifluoromethyl)-1H-1,2,4-triazol-3-yl]imidazo[1,2-a]pyrazine |
| Molecular Formula | C16H10F4N6 |
| Purity | ≥95% |
| IUPAC Name | 8-[(2-fluorophenyl)methyl]-6-[5-(trifluoromethyl)-1H-1,2,4-triazol-3-yl]imidazo[1,2-a]pyrazine |
| InChI | InChI=1S/C16H10F4N6/c17-10-4-2-1-3-9(10)7-11-14-21-5-6-26(14)8-12(22-11)13-23-15(25-24-13)16(18,19)20/h1-6,8H,7H2,(H,23,24,25) |
| InChIKey | GTKNNCQKFKGSHR-UHFFFAOYSA-N |
| SMILES | C1=CC=C(C(=C1)CC2=NC(=CN3C2=NC=C3)C4=NNC(=N4)C(F)(F)F)F |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
