For research use only. Not for therapeutic Use.
Zabedosertib (Cat No.:I038652) is a selective, orally bioavailable inhibitor of Ataxia Telangiectasia and Rad3-related protein (ATR), a key regulator of the DNA damage response. By inhibiting ATR, zabedosertib disrupts the repair of replication stress and DNA damage in tumor cells, leading to genomic instability and cell death—particularly in cancers with defective DNA repair pathways such as ATM or BRCA mutations. It is being explored in preclinical and early clinical studies for its potential in combination therapies targeting solid tumors and hematologic malignancies reliant on ATR signaling.
| CAS Number | 1931994-81-8 |
| Synonyms | N-[6-(2-hydroxypropan-2-yl)-2-(2-methylsulfonylethyl)indazol-5-yl]-6-(trifluoromethyl)pyridine-2-carboxamide |
| Molecular Formula | C20H21F3N4O4S |
| Purity | ≥95% |
| IUPAC Name | N-[6-(2-hydroxypropan-2-yl)-2-(2-methylsulfonylethyl)indazol-5-yl]-6-(trifluoromethyl)pyridine-2-carboxamide |
| InChI | InChI=1S/C20H21F3N4O4S/c1-19(2,29)13-10-15-12(11-27(26-15)7-8-32(3,30)31)9-16(13)25-18(28)14-5-4-6-17(24-14)20(21,22)23/h4-6,9-11,29H,7-8H2,1-3H3,(H,25,28) |
| InChIKey | OQAMEEFUUFJZRS-UHFFFAOYSA-N |
| SMILES | CC(C)(C1=CC2=NN(C=C2C=C1NC(=O)C3=NC(=CC=C3)C(F)(F)F)CCS(=O)(=O)C)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
