For research use only. Not for therapeutic Use.
Z-YVAD-FMK(CAT: I046032) is a cell-permeable, irreversible inhibitor of caspase-1 and caspase-4, widely used in apoptosis and inflammation research. By blocking caspase-1–mediated processing of pro-inflammatory cytokines such as IL-1β, Z-YVAD-FMK exhibits anti-inflammatory activity and has also been shown to exert anti-tumor effects in various models. In Caco-2 cells, treatment with Z-YVAD-FMK attenuates butyrate-induced growth inhibition, while in HepG2 and BEL-7402 cells it reduces III-10–induced apoptosis in a dose-dependent manner. As a selective caspase inhibitor, Z-YVAD-FMK is an essential research tool for studying inflammasome activation, apoptosis pathways, tumor biology, and therapeutic approaches targeting caspase signaling.
| CAS Number | 210344-97-1 |
| Synonyms | methyl (3S)-5-fluoro-3-[[(2S)-2-[[(2S)-2-[[(2S)-3-(4-hydroxyphenyl)-2-(phenylmethoxycarbonylamino)propanoyl]amino]-3-methylbutanoyl]amino]propanoyl]amino]-4-oxopentanoate |
| Molecular Formula | C31H39FN4O9 |
| Purity | ≥95% |
| InChI | InChI=1S/C31H39FN4O9/c1-18(2)27(30(42)33-19(3)28(40)34-23(25(38)16-32)15-26(39)44-4)36-29(41)24(14-20-10-12-22(37)13-11-20)35-31(43)45-17-21-8-6-5-7-9-21/h5-13,18-19,23-24,27,37H,14-17H2,1-4H3,(H,33,42)(H,34,40)(H,35,43)(H,36,41)/t19-,23-,24-,27-/m0/s1 |
| InChIKey | MVPQJUFFTWWKBT-LBDWYMBGSA-N |
| SMILES | CC(C)C(C(=O)NC(C)C(=O)NC(CC(=O)OC)C(=O)CF)NC(=O)C(CC1=CC=C(C=C1)O)NC(=O)OCC2=CC=CC=C2 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
