Z-VRPR-FMK TFA

• CAT Number: I046119
• Molecular Formula: C33H50F4N10O8
• Molecular Weight: 790.81
• Purity: ≥95%
• Synonyms: benzyl N-[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-[(2S)-2-[[6-(diaminomethylideneamino)-1-fluoro-2-oxohexan-3-yl]carbamoyl]pyrrolidin-1-yl]-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]carbamate;2,2,2-trifluoroacetic acid
• InChI: InChI=1S/C31H49FN10O6.C2HF3O2/c1-19(2)25(41-31(47)48-18-20-9-4-3-5-10-20)27(45)40-22(12-7-15-38-30(35)36)28(46)42-16-8-13-23(42)26(44)39-21(24(43)17-32)11-6-14-37-29(33)34;3-2(4,5)1(6)7/h3-5,9-10,19,21-23,25H,6-8,11-18H2,1-2H3,(H,39,44)(H,40,45)(H,41,47)(H4,33,34,37)(H4,35,36,38);(H,6,7)/t21?,22-,23-,25-;/m0./s1
• InChIKey: WIPHXOQUHDJLCU-WTJMUODPSA-N
• SMILES: CC(C)[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)NC(CCCN=C(N)N)C(=O)CF)NC(=O)OCC2=CC=CC=C2.C(=O)(C(F)(F)F)O

Z-VRPR-FMK TFA（Cat No.:I046119）is a synthetic peptide-based irreversible inhibitor of granzyme B, supplied as its trifluoroacetate salt. The peptide sequence Val-Arg-Pro-Arg (VRPR) is conjugated with a fluoromethyl ketone (FMK) warhead, enabling covalent modification of the enzyme’s active site cysteine. Z-VRPR-FMK is widely used in immunology and apoptosis research to study cytotoxic T lymphocyte and natural killer (NK) cell–mediated pathways. By selectively blocking granzyme B–induced apoptosis, it helps dissect immune effector mechanisms, evaluate therapeutic targets, and investigate immune regulation in cancer, infection, and inflammatory disease models.