For research use only. Not for therapeutic Use.
Z-VDVAD-FMK（Cat No.:I044765）is a cell-permeable, irreversible caspase-2 inhibitor that binds covalently to the active site cysteine, blocking apoptosis-related pathways. It consists of a peptide sequence (Z-Val-Asp-Val-Ala-Asp) and a fluoromethyl ketone (FMK) reactive group, allowing specific inhibition of caspase-2 without significantly affecting other caspases. This makes it a valuable tool for studying cell death mechanisms, particularly in neurodegeneration, cancer, and immune system disorders. Z-VDVAD-FMK is widely used in research to dissect caspase-dependent apoptotic events and evaluate therapeutic strategies targeting programmed cell death.
| CAS Number | 210344-92-6 |
| Synonyms | methyl (3S)-5-fluoro-3-[[(2S)-2-[[(2S)-2-[[(2S)-4-methoxy-2-[[(2S)-3-methyl-2-(phenylmethoxycarbonylamino)butanoyl]amino]-4-oxobutanoyl]amino]-3-methylbutanoyl]amino]propanoyl]amino]-4-oxopentanoate |
| Molecular Formula | C32H46FN5O11 |
| Purity | ≥95% |
| IUPAC Name | methyl 5-fluoro-3-[2-[[2-[[4-methoxy-2-[[3-methyl-2-(phenylmethoxycarbonylamino)butanoyl]amino]-4-oxobutanoyl]amino]-3-methylbutanoyl]amino]propanoylamino]-4-oxopentanoate |
| InChI | InChI=1S/C32H46FN5O11/c1-17(2)26(30(44)34-19(5)28(42)35-21(23(39)15-33)13-24(40)47-6)37-29(43)22(14-25(41)48-7)36-31(45)27(18(3)4)38-32(46)49-16-20-11-9-8-10-12-20/h8-12,17-19,21-22,26-27H,13-16H2,1-7H3,(H,34,44)(H,35,42)(H,36,45)(H,37,43)(H,38,46) |
| InChIKey | ANTIWMNLIROOQF-UHFFFAOYSA-N |
| SMILES | CC(C)C(C(=O)NC(C)C(=O)NC(CC(=O)OC)C(=O)CF)NC(=O)C(CC(=O)OC)NC(=O)C(C(C)C)NC(=O)OCC1=CC=CC=C1 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
