Z-Nle-Lys-Arg-AMC acetate

• CAT Number: I040219
• Molecular Formula: C36H50N8O7.xC2H4O2
• Molecular Weight: 706.83 (free base)
• Purity: ≥95%

Z-Nle-Lys-Arg-AMC acetate(CAT: I040219) is a fluorogenic peptide substrate designed for the specific detection of cathepsin B activity. Incorporating 7-amino-4-methylcoumarin (AMC) as the fluorescent leaving group, this substrate releases a measurable fluorescent signal upon enzymatic cleavage. Its sequence is optimized for high selectivity toward cathepsin B, enabling precise activity monitoring across a broad pH range. This makes it ideal for enzymatic assays in complex biological environments, including lysosomal activity profiling and inhibitor screening. Z-Nle-Lys-Arg-AMC acetate is widely used in cancer, inflammation, and neurodegeneration research, where cathepsin B plays a critical role in proteolysis and disease progression.